113 Result(s)
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Effects of La3+ and Gd3+ on Ca2+ influx in rat hepatoma H-35 cells
Effects of La3+ and Gd3+ on Ca2+ influx were investigated in rat hepatoma H-35 cells by measuring the initial rate of45Ca2+ uptake. It was found that the maximum initial rate of Ca2+ uptake was increased six-to t...
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Recycling lower continental crust in the North China craton
Foundering of mafic lower continental crust into underlying convecting mantle has been proposed as one means to explain the unusually evolved chemical composition of Earth's continental crust1,2, yet direct evide...
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A eudicot from the Early Cretaceous of China
The early history of flowering plants (angiosperms) is contentious, but a steady stream of fossil discoveries from the Early Cretaceous of China is beginning to fill in some of the gaps in our knowledge. The l...
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Evidence for several waves of global transmission in the seventh cholera pandemic
Cholera has affected human populations for centuries, and the agent responsible, Vibrio cholerae, continues to infect millions each year. Using whole genome phylogeny, it is now shown that the current seventh epi...
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Open AccessThe genetic basis of early T-cell precursor acute lymphoblastic leukaemia
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases and assessed the frequency of the i...
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T-cell differentiation factor CBF-β regulates HIV-1 Vif-mediated evasion of host restriction
CBF-β is shown to regulate the ability of HIV-1 to evade host restriction mediated by the deaminase APOBEC3.
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The genesis and source of the H7N9 influenza viruses causing human infections in China
Evolutionary analyses show that H7 influenza viruses probably transferred from ducks to chickens in China on at least two independent occasions, and that reassortment with H9N2 viruses generated the H7N9 outbr...
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Open AccessLayered SiC Sheets: A Potential Catalyst for Oxygen Reduction Reaction
The large-scale practical application of fuel cells cannot come true if the high-priced Pt-based electrocatalysts for oxygen reduction reaction (ORR) cannot be replaced by other efficient, low-cost and stable ...
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C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma
Members of the nuclear factor-κB (NF-κB) family of transcriptional regulators are central mediators of the cellular inflammatory response. Although constitutive NF-κB signalling is present in most human tumour...
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Correction: Corrigendum: C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma
Nature 506, 451–455 (2014); doi:10.1038/nature13109 In this Article, author Jared Becksfort’s surname was incorrectly spelled ‘Becksford’. Also, his affiliation should be the Department of Computational Biolog...
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The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes
Studies of paediatric cancers have shown a high frequency of mutation across epigenetic regulators. Here we sequence 633 genes, encoding the majority of known epigenetic regulatory proteins, in over 1,000 paed...
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Open AccessPressure-Induced Magnetic Crossover Driven by Hydrogen Bonding in CuF2(H2O)2(3-chloropyridine)
Hydrogen bonding plays a foundational role in the life, earth and chemical sciences, with its richness and strength depending on the situation. In molecular materials, these interactions determine assembly mec...
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Efficient and tuneable photoluminescent boehmite hybrid nanoplates lacking metal activator centres for single-phase white LEDs
White light-emitting diodes (WLEDs) are candidates to revolutionize the lighting industry towards energy efficient and environmental friendly lighting and displays. The current challenges in WLEDs encompass hi...
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Charge order and its connection with Fermi-liquid charge transport in a pristine high-Tc cuprate
Electronic inhomogeneity appears to be an inherent characteristic of the enigmatic cuprate superconductors. Here we report the observation of charge–density–wave correlations in the model cuprate superconducto...
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Chiral recognition and selection during the self-assembly process of protein-mimic macroanions
The research on chiral recognition and chiral selection is not only fundamental in resolving the puzzle of homochirality, but also instructive in chiral separation and stereoselective catalysis. Here we report...
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Open AccessRise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia
There is incomplete understanding of genetic heterogeneity and clonal evolution during cancer progression. Here we use deep whole-exome sequencing to describe the clonal architecture and evolution of 20 pediat...
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Open AccessRevealing Missing Human Protein Isoforms Based on Ab Initio Prediction, RNA-seq and Proteomics
Biological and biomedical research relies on comprehensive understanding of protein-coding transcripts. However, the total number of human proteins is still unknown due to the prevalence of alternative splicin...
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Open AccessThe effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction
Animals have to adjust their activities when faced with caloric restriction (CR) to deal with reduced energy intake. If CR is pronounced, allostasis can push individuals into alternate physiological states whi...
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Open AccessPreparation of topological modes by Lyapunov control
By Lyapunov control, we present a proposal to drive quasi-particles into a topological mode in quantum systems described by a quadratic Hamiltonian. The merit of this control is the individual manipulations on...
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An introductory report on the biodiversity of Middle Jurassic Phoenicopsis (Czekanowskiales) from the Ordos Basin, China
Although the genus Phoenicopsis is the most common member of Czekanowskiales and is considered an indicative representative of the Middle Jurassic Coniopteris–Phoenicopsis assemblage in northern China, little was...