26 Result(s)

Article

Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1

TP53 mutations occur in many different types of cancers that produce mutant p53 proteins. The mutant p53 proteins have lost wild-type p53 activity and gained new functions that contribute to malignant tumor pr...

Ling Fang, William W. Du, Juanjuan Lyu, Jun Dong… in Cell Death & Differentiation (2018)

Article

De-ubiquitinating enzyme, USP11, promotes transforming growth factor β-1 signaling through stabilization of transforming growth factor β receptor II

The transforming growth factor β-1 (TGFβ-1) signaling pathway plays a central role in the pathogenesis of pulmonary fibrosis. Two TGFβ-1 receptors, TβRI and TβRII, mediate this pathway. TβRI protein stability, as...

A M Jacko, L Nan, S Li, J Tan, J Zhao, D J Kass, Y Zhao in Cell Death & Disease (2016)

Article

Engineered adenovirus fiber shaft fusion homotrimer of soluble TRAIL with enhanced stability and antitumor activity

Successful cancer therapies aim to induce selective apoptosis in neoplastic cells. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered an attractive anticancer agent due to its tumor ...

J Yan, L Wang, Z Wang, Z Wang, B Wang, R Zhu, J Bi, J Wu, H Zhang… in Cell Death & Disease (2016)

Article

Diet-driven interferon-γ enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy

X-j **a, Y-y Che, J Zhang, Y-y Gao, C-j Ao, H-j Yang, J-x Liu… in Cell Death & Disease (2016)

Article

Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-γ-induced malignant transformation of primary bovine mammary epithelial cells

Autophagy has been linked to the regulation of both the prevention and progression of cancer. IFN-γ has been shown to induce autophagy in multiple cell lines in vitro. However, whether IFN-γ can induce autophagy ...

X-j **a, Y-y Gao, J Zhang, L Wang, S Zhao, Y-y Che, C-j Ao… in Cell Death Discovery (2016)

Article

JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein

Primary human fibroblasts undergoing oncogene-induced or replicative senescence are known to form senescence-associated heterochromatin foci (SAHF), which can stabilize the state of senescence. The retinoblast...

L Zhao, Y Zhang, Y Gao, P Geng, Y Lu, X Liu, R Yao, P Hou… in Cell Death & Differentiation (2015)

Article

The potential of mesenchymal stem cells in the management of radiation enteropathy

Although radiotherapy is effective in managing abdominal and pelvic malignant tumors, radiation enteropathy is still unavoidable. This disease severely affects the quality of life of cancer patients due to som...

P-Y Chang, Y-Q Qu, J Wang, L-H Dong in Cell Death & Disease (2015)

Article

Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression

The high mortality in breast cancer is often associated with metastatic progression in patients. Previously we have demonstrated that testes-specific protease 50 (TSP50), an oncogene overexpressed in breast ca...

Z B Song, J-S Ni, P Wu, Y L Bao, T Liu, M Li, C Fan, W J Zhang… in Cell Death & Disease (2015)

Article

Direct optic nerve sheath (DONS) application of Schwann cells prolongs retinal ganglion cell survival in vivo

Cell-based therapies are increasingly recognized as a potential strategy to treat retinal neurodegenerative disease. Their administration, however, is normally indirect and complex, often with an inability to ...

L Guo, B Davis, S Nizari, E M Normando, H Shi, J Galvao, L Turner… in Cell Death & Disease (2014)

Article

LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis

LncRNAs have critical roles in various biological processes ranging from embryonic development to human diseases, including cancer progression, although their detailed mechanistic functions remain illusive. Th...

P Hou, Y Zhao, Z Li, R Yao, M Ma, Y Gao, L Zhao, Y Zhang, B Huang… in Cell Death & Disease (2014)

Article

Liver kinase B1 regulates the centrosome via PLK1

Liver kinase B1 (LKB1) is a tumor suppressor mutationally inactivated in Peutz–Jeghers syndrome (PJS) and various sporadic cancers. Although LKB1 encodes a kinase that possesses multiple functions, no individu...

K Werle, J Chen, H-G Xu, R-X Zhao, Q He, C Lu, R Cui, J Liang… in Cell Death & Disease (2014)

Article

Piperlongumine induces autophagy by targeting p38 signaling

Piperlongumine (PL), a natural product isolated from the plant species Piper longum L., can selectively induce apoptotic cell death in cancer cells by targeting the stress response to reactive oxygen species (...

Y Wang, J-W Wang, X **ao, Y Shan, B Xue, G Jiang, Q He, J Chen… in Cell Death & Disease (2013)