57 Result(s)

Article

Expression profiling of the schizont and trophozoite stages of Plasmodium falciparumwith a long-oligonucleotide microarray

The worldwide persistence of drug-resistant Plasmodium falciparum, the most lethal variety of human malaria, is a global health concern. The P. falciparum sequencing project has brought new opportunities for iden...

Zbynek Bozdech, **gchun Zhu, Marcin P Joachimiak, Fred E Cohen… in Genome Biology (2003)

Article

Statistical identification of gene association by CID in application of constructing ER regulatory network

A variety of high-throughput techniques are now available for constructing comprehensive gene regulatory networks in systems biology. In this study, we report a new statistical approach for facilitating in silico

Li-Yu D Liu, Chien-Yu Chen, Mei-Ju M Chen, Ming-Shian Tsai… in BMC Bioinformatics (2009)

Article

Immune responses in pigs induced by recombinant canine adenovirus 2 expressing the glycoprotein 5 of porcine reproductive and respiratory syndrome virus

To develop a new type vaccine for porcine reproductive and respiratory syndrome (PRRS) prevention by using canine adenovirus 2(CAV-2) as vector, the Glycoprotein 5(GP5) gene from PRRSV strain JL was amplified ...

J.-X. Zhou, J.-D. Xue, T. Yu, J.-B. Zhang, Y. Liu… in Veterinary Research Communications (2010)

Article

ATAQS: A computational software tool for high throughput transition optimization and validation for selected reaction monitoring mass spectrometry

Since its inception, proteomics has essentially operated in a discovery mode with the goal of identifying and quantifying the maximal number of proteins in a sample. Increasingly, proteomic measurements are al...

Mi-Youn K Brusniak, Sung-Tat Kwok, Mark Christiansen, David Campbell… in BMC Bioinformatics (2011)

Article

RNA-Seq analysis implicates dysregulation of the immune system in schizophrenia

While genome-wide association studies identified some promising candidates for schizophrenia, the majority of risk genes remained unknown. We were interested in testing whether integration gene expression and ...

Junzhe Xu, **gchun Sun, **gchun Chen, Lily Wang, Anna Li, Matthew Helm… in BMC Genomics (2012)

Article

Piperlongumine induces autophagy by targeting p38 signaling

Piperlongumine (PL), a natural product isolated from the plant species Piper longum L., can selectively induce apoptotic cell death in cancer cells by targeting the stress response to reactive oxygen species (...

Y Wang, J-W Wang, X **ao, Y Shan, B Xue, G Jiang, Q He, J Chen… in Cell Death & Disease (2013)

Article

Liver kinase B1 regulates the centrosome via PLK1

Liver kinase B1 (LKB1) is a tumor suppressor mutationally inactivated in Peutz–Jeghers syndrome (PJS) and various sporadic cancers. Although LKB1 encodes a kinase that possesses multiple functions, no individu...

K Werle, J Chen, H-G Xu, R-X Zhao, Q He, C Lu, R Cui, J Liang… in Cell Death & Disease (2014)

Article

LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis

LncRNAs have critical roles in various biological processes ranging from embryonic development to human diseases, including cancer progression, although their detailed mechanistic functions remain illusive. Th...

P Hou, Y Zhao, Z Li, R Yao, M Ma, Y Gao, L Zhao, Y Zhang, B Huang… in Cell Death & Disease (2014)

Article

Multi-locus phylogeny of lethal amanitas: Implications for species diversity and historical biogeography

Lethal amanitas (Amanita section Phalloideae) are a group of wild, fatal mushrooms causing many poisoning cases worldwide. However, the diversity and evolutionary history of these lethal mushrooms remain poorly k...

Qing Cai, Rodham E Tulloss, Li P Tang, Bau Tolgor, ** Zhang… in BMC Evolutionary Biology (2014)

Article

Direct optic nerve sheath (DONS) application of Schwann cells prolongs retinal ganglion cell survival in vivo

Cell-based therapies are increasingly recognized as a potential strategy to treat retinal neurodegenerative disease. Their administration, however, is normally indirect and complex, often with an inability to ...

L Guo, B Davis, S Nizari, E M Normando, H Shi, J Galvao, L Turner… in Cell Death & Disease (2014)

Article

Bridger: a new framework for de novo transcriptome assembly using RNA-seq data

We present a new de novo transcriptome assembler, Bridger, which takes advantage of techniques employed in Cufflinks to overcome limitations of the existing de novo assemblers. When tested on dog, human, and mous...

Zheng Chang, Guojun Li, Juntao Liu, Yu Zhang, Cody Ashby, Deli Liu… in Genome Biology (2015)

Article

Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression

The high mortality in breast cancer is often associated with metastatic progression in patients. Previously we have demonstrated that testes-specific protease 50 (TSP50), an oncogene overexpressed in breast ca...

Z B Song, J-S Ni, P Wu, Y L Bao, T Liu, M Li, C Fan, W J Zhang… in Cell Death & Disease (2015)

Article

Heterologous expression and transcript analysis of gibberellin biosynthetic genes of grasses reveals novel functionality in the GA3ox family

The gibberellin (GA) pathway plays a central role in the regulation of plant development, with the 2-oxoglutarate-dependent dioxygenases (2-ODDs: GA20ox, GA3ox, GA2ox) that catalyse the later steps in the bios...

Stephen Pearce, Alison K Huttly, Ian M Prosser, Yi-dan Li… in BMC Plant Biology (2015)

Article

The potential of mesenchymal stem cells in the management of radiation enteropathy

Although radiotherapy is effective in managing abdominal and pelvic malignant tumors, radiation enteropathy is still unavoidable. This disease severely affects the quality of life of cancer patients due to som...

P-Y Chang, Y-Q Qu, J Wang, L-H Dong in Cell Death & Disease (2015)

Article

JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein

Primary human fibroblasts undergoing oncogene-induced or replicative senescence are known to form senescence-associated heterochromatin foci (SAHF), which can stabilize the state of senescence. The retinoblast...

L Zhao, Y Zhang, Y Gao, P Geng, Y Lu, X Liu, R Yao, P Hou… in Cell Death & Differentiation (2015)

Article

Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-γ-induced malignant transformation of primary bovine mammary epithelial cells

Autophagy has been linked to the regulation of both the prevention and progression of cancer. IFN-γ has been shown to induce autophagy in multiple cell lines in vitro. However, whether IFN-γ can induce autophagy ...

X-j **a, Y-y Gao, J Zhang, L Wang, S Zhao, Y-y Che, C-j Ao… in Cell Death Discovery (2016)

Article

Diet-driven interferon-γ enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy

X-j **a, Y-y Che, J Zhang, Y-y Gao, C-j Ao, H-j Yang, J-x Liu… in Cell Death & Disease (2016)

Article

Engineered adenovirus fiber shaft fusion homotrimer of soluble TRAIL with enhanced stability and antitumor activity

Successful cancer therapies aim to induce selective apoptosis in neoplastic cells. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered an attractive anticancer agent due to its tumor ...

J Yan, L Wang, Z Wang, Z Wang, B Wang, R Zhu, J Bi, J Wu, H Zhang… in Cell Death & Disease (2016)

Article

De-ubiquitinating enzyme, USP11, promotes transforming growth factor β-1 signaling through stabilization of transforming growth factor β receptor II

The transforming growth factor β-1 (TGFβ-1) signaling pathway plays a central role in the pathogenesis of pulmonary fibrosis. Two TGFβ-1 receptors, TβRI and TβRII, mediate this pathway. TβRI protein stability, as...

A M Jacko, L Nan, S Li, J Tan, J Zhao, D J Kass, Y Zhao in Cell Death & Disease (2016)

Article

Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) driven by oncogenic K-Ras remains among the most lethal human cancers despite recent advances in modern medicine. The pathogenesis of PDAC is partly attributable to intr...

Rui Kang, Yangchun **e, Qiuhong Zhang, Wen Hou, Qing** Jiang, Shan Zhu… in Cell Research (2017)