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  1. Article

    Open Access

    Diagnostic accuracy of an artificial neural network compared with statistical quantitation of myocardial perfusion images: a Japanese multicenter study

    Artificial neural networks (ANN) might help to diagnose coronary artery disease. This study aimed to determine whether the diagnostic accuracy of an ANN-based diagnostic system and conventional quantitation ar...

    Kenichi Nakajima, Takashi Kudo… in European Journal of Nuclear Medicine and M… (2017)

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  2. No Access

    Article

    In vitro detection of mdr1 mRNA in murine leukemia cells with 111In-labeled oligonucleotide

    The feasibility of intracellular mdr1 mRNA expression detection with radiolabeled antisense oligonucleotide (ODN) was investigated in the murine leukemia cell line, P388/S, and its subclonal, adriamycin-resistant...

    **gming Bai, Kunihiko Yokoyama… in European Journal of Nuclear Medicine and M… (2004)

  3. No Access

    Article

    Improved survival of mice bearing liver metastases of colon cancer cells treated with a combination of radioimmunotherapy and antiangiogenic therapy

    We attempted to determine whether the combined regimen of radioimmunotherapy (RIT) and antiangiogenic therapy would favorably affect the survival of animals bearing liver metastases of colon cancer cells. Dail...

    Seigo Kinuya, Kunihiko Yokoyama… in European Journal of Nuclear Medicine and M… (2004)

  4. No Access

    Article

    Reduction of 99mTc-sestamibi and 99mTc-tetrofosmin uptake in MRP-expressing breast cancer cells under hypoxic conditions is independent of MRP function

    Hypoxia reduces the uptake of technetium-99m sestamibi (MIBI) in human cancer cell lines. In the current investigation, we attempted to identify the relationship between hypoxia-induced alteration of 99mTc-MIBI a...

    Seigo Kinuya, **ao-Feng Li… in European Journal of Nuclear Medicine and M… (2003)

  5. No Access

    Article

    Local delivery of 131I-MIBG to treat peritoneal neuroblastoma

    Internal radiotherapy involving systemic administration of iodine-131 metaiodobenzylguanidine (131I-MIBG) in neural crest tumours such as neuroblastoma has shown considerable success. Although peritoneal seeding ...

    Seigo Kinuya, **ao-Feng Li… in European Journal of Nuclear Medicine and M… (2003)

  6. No Access

    Article

    Benefits of combined radioimmunotherapy and anti-angiogenic therapy in a liver metastasis model of human colon cancer cells

    The combined use of anti-angiogenic therapy (AT) and radioimmunotherapy (RIT) may improve the therapeutic outcome in patients with cancer lesions. This hypothesis is based on the ability of AT to suppress tum...

    **ao-Feng Li, Seigo Kinuya… in European Journal of Nuclear Medicine and M… (2002)

  7. No Access

    Article

    Hypoxia-induced alteration of tracer accumulation in cultured cancer cells and xenografts in mice: implications for pre-therapeutic prediction of treatment outcomes with 99mTc-sestamibi, 201Tl chloride and 99mTc-HL91

    Weak visualization of tumours in pre-therapeutic scintigrams with technetium-99m sestamibi (MIBI) is likely a predictive sign of unfavourable tumour response to radiotherapy and chemotherapy. However, factors...

    Seigo Kinuya, Kunihiko Yokoyama… in European Journal of Nuclear Medicine and M… (2002)

  8. No Access

    Article

    Anti-angiogenic therapy and radioimmunotherapy in colon cancer xenografts

    Angiogenesis is critical to the growth and metastatic process of malignant tumors. An endogenous estrogen metabolite, 2-methoxyestradiol (2-ME), displays anti-angiogenic and anti-tumorigenic effects. The purp...

    Seigo Kinuya, Atsuhiro Kawashima, Kunihiko Yokoyama… in European Journal of Nuclear Medicine (2001)

  9. No Access

    Article

    Improved response of colon cancer xenografts to radioimmunotherapy with pentoxifylline treatment

    A methylxanthine, pentoxifylline (PTX), has the potential to improve tumour microcirculation and oxygenation in vivo. We aimed to determine whether this agent would enhance the response of tumours to experime...

    Seigo Kinuya, Kunihiko Yokoyama, Shota Konishi… in European Journal of Nuclear Medicine (2001)

  10. No Access

    Article

    Visualization of the thymus with therapeutic doses of radioiodine in patients with thyroid cancer

    Two cases of papillary carcinoma of the thyroid are presented in which whole-body scans following therapeutic doses of iodine-131 revealed intense anterior mediastinal uptake. In both cases, the mediastinal up...

    Takatoshi Michigishi, Yuji Mizukami, Noriyuki Shuke… in European Journal of Nuclear Medicine (1993)

  11. No Access

    Article

    Observation of portal circulation through superior mesenteric vein by enteric coated capsule of thallium-201

    A new method of oral administration of an enteric coated capsule of 201Tl (201Tl-capsule) was developed to evaluate the portal circulation through the superior mesenteric vein (SMV). The 201Tl-capsule was not col...

    Norihisa Tonami, Kenichi Nakajima, Naoto Watanabe… in European Journal of Nuclear Medicine (1988)

  12. No Access

    Article

    The utility of radionuclide myelography and cisternography in the progress of cerebrospinal fluid leaks

    Three cases of CSF leaks that did not communicate with the body surface were diagnosed and followed using radionuclide myelography or cisternography. The utility and advantages of this definitive diagnostic me...

    Toshio Maeda, Hiroko Ishida, Hiroshi Matsuda… in European Journal of Nuclear Medicine (1984)