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  1. Article

    Antimicrobial properties of L-amino acid oxidase: biochemical features and biomedical applications

    Mucus layer that covers the body surface of various animal functions as a defense barrier against microbes, environmental xenobiotics, and predators. Previous studies have reported that L-amino acid oxidase (L...

    Kosuke Kasai, Manabu Nakano, Masami Ohishi in Applied Microbiology and Biotechnology (2021)

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    Article

    Metal coordination by L-amino acid oxidase derived from flounder Platichthys stellatus is structurally essential and regulates antibacterial activity

    L-amino acid oxidases (LAAOs) have antibacterial activity and play important roles in innate immunity. We have previously identified a LAAO of ~52 kDa in size from the mucus layer of the flounder Platichthys stel...

    Kosuke Kasai, Yudai Ito, Akihide Nitta in Applied Microbiology and Biotechnology (2020)

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    Article

    Antibacterial properties of l-amino acid oxidase: mechanisms of action and perspectives for therapeutic applications

    Venom, the mucus layer covering the body surface, ink glands, mammary glands, milk, and various animal secretory functions as both a physical and chemical defense barrier against bacteria and virus infections....

    Kosuke Kasai, Takashi Ishikawa, Toshiya Nakamura in Applied Microbiology and Biotechnology (2015)

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    Article

    Recombinant production and evaluation of an antibacterial l-amino acid oxidase derived from flounder Platichthys stellatus

    Fish produce mucus substances as a defensive outer barrier against several bacterial infections. We have recently identified an antibacterial l-amino acid oxidase (psLAAO1) in the mucus layer of the flounder Plat...

    Kosuke Kasai, Kenro Hashiguchi, Hiroki Takahashi in Applied Microbiology and Biotechnology (2015)