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Approaches for characterizing and tracking hospital-associated multidrug-resistant bacteria

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  1. Article

    Open Access

    Sequence-structure-function characterization of the emerging tetracycline destructase family of antibiotic resistance enzymes

    Tetracycline destructases (TDases) are flavin monooxygenases which can confer resistance to all generations of tetracycline antibiotics. The recent increase in the number and diversity of reported TDase sequen...

    Kevin S. Blake, Hirdesh Kumar, Anisha Loganathan… in Communications Biology (2024)

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  2. Article

    Open Access

    Publisher Correction: Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases

    Hirdesh Kumar, Emily E. Williford, Kevin S. Blake… in Communications Biology (2023)

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  3. Article

    Open Access

    Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases

    Inactivation of tetracycline antibiotics by tetracycline destructases (TDases) remains a clinical and agricultural threat. TDases can be classified as type 1 Tet(X)-like TDases and type 2 soil-derived TDases. ...

    Hirdesh Kumar, Emily E. Williford, Kevin S. Blake… in Communications Biology (2023)

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