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  1. Article

    Open Access

    Effectiveness of empirical anti-pseudomonal antibiotics for recurrent COPD exacerbation: a multicenter retrospective cohort study

    Although frequent chronic obstructive pulmonary disease (COPD) exacerbation has been associated with the isolation of Pseudomonas aeruginosa (PA) in sputum cultures, it remains unknown whether the empirical use o...

    Akihiro Shiroshita, Chisato Miyakoshi, Shunta Tsutsumi, Hiroshi Shiba… in Scientific Reports (2021)

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  2. Article

    Open Access

    Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing

    Genetically modified nonhuman primates (NHP) are useful models for biomedical research. Gene editing technologies have enabled production of target-gene knock-out (KO) NHP models. Target-gene-KO/knock-in (KI) ...

    Wakako Kumita, Kenya Sato, Yasuhiro Suzuki, Yoko Kurotaki… in Scientific Reports (2019)

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