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Article
Open AccessDifferential acute impact of therapeutically effective and overdose concentrations of lithium on human neuronal single cell and network function
Lithium salts are used as mood-balancing medication prescribed to patients suffering from neuropsychiatric disorders, such as bipolar disorder and major depressive disorder. Lithium salts cross the blood-brain...
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Article
Open AccessIdentification of candidate genetic variants and altered protein expression in neural stem and mature neural cells support altered microtubule function to be an essential component in bipolar disorder
Identification of causative genetic variants leading to the development of bipolar disorder (BD) could result in genetic tests that would facilitate diagnosis. A better understanding of affected genes and path...
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Article
Open AccessTLX—Its Emerging Role for Neurogenesis in Health and Disease
The orphan nuclear receptor TLX, also called NR2E1, is a factor important in the regulation of neural stem cell (NSC) self-renewal, neurogenesis, and maintenance. As a transcription factor, TLX is vital for th...
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Article
Open AccessThe Roles of PDGF in Development and During Neurogenesis in the Normal and Diseased Nervous System
The four platelet-derived growth factor (PDGF) ligands and PDGF receptors (PDGFRs), α and β (PDGFRA, PDGFRB), are essential proteins that are expressed during embryonic and mature nervous systems, i.e., in neu...
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Article
Sp1 is a key regulator of the PDGF β-receptor transcription
The mouse PDGF β-receptor promoter is tightly controlled by NF-Y that binds to a CCAAT box located upstream of the initiation site [1, 2]. In this report, we show that Sp1 plays an essential role in the PDGF β...
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Article
Expression of transforming growth factor-β1, 2, 3 isoforms and type I and II receptors in acute focal cerebral ischemia: an immunohistochemical study in rat after transient and permanent occlusion of middle cerebral artery
Transforming growth factor beta (TGF-β) is involved in the modulation of cell growth, differentiation and repair following injury of various organs. Previous studies on human autopsy material have indicated t...
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Article
Expression of various TGF-β isoforms and type I receptor in necrotizing human brain lesions
It is known that transforming growth factor beta (TGF-β) is involved in the modulation of cell growth, differentiation, and repair following injury. We performed an immunohistochemical study of human brain au...
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Article
Specific effects of platelet derived growth factor (PDGF) on fetal rat and human dopaminergic neurons in vitro
The neurotrophic effects of the BB isoform of platelet-derived growth factor (PDGF) on rat and human fetal mesencephalic dopaminergic neurons have been characterized in vitro. A dose-response analysis demonstr...
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Article
PDGF and its receptors following facial nerve axotomy in rats: expression in neurons and surrounding glia
We investigated the expression of platelet-derived growth factor (PDGF) and its receptors in rat facial nuclei following axotomy by in situ hybridization and immunohistochemistry. Facial nuclei were examined o...
