24 Result(s)
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Article
Quantitative assessment of cerebral blood flow using Technetium-99m-hexamethyl-propyleneamine oxime: Part I, design of a mathematical model
To design a mathematical model for quantifying cerebral blood flow using99mTc-hexamethylpropyleneamine oxime (HM-PAO), basic studies were performed in animals and human volunteers. Microautoradiography revealed t...
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Article
Discrepancy between blood flow and muscarinic receptor distribution in rat brain after middle cerebral artery occlusion
To clarify whether muscarinic acetylcholine receptor (mAChR) binding can be a viable muscarinic neuronal marker which provides therapeutic information different from perfusional information in global brain, we...
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Article
Benefits of combined radioimmunotherapy and anti-angiogenic therapy in a liver metastasis model of human colon cancer cells
The combined use of anti-angiogenic therapy (AT) and radioimmunotherapy (RIT) may improve the therapeutic outcome in patients with cancer lesions. This hypothesis is based on the ability of AT to suppress tum...
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Article
Feasibility of 186Re-radioimmunotherapy for treatment in an adjuvant setting of colon cancer
186Re displays abundant intermediate energy β emission, and possesses an appropriate physical half-life of 3.7 days. We compared the efficacy of radioimmunotherapy (RIT) with an anti-colorectal cancer monoclonal...
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Article
Evaluation of radioiodinated (−)-o-iodovesamicol as a radiotracer for map** the vesicular acetylcholine transporter
We evaluated the potencies of radioiodinated (−)-o-iodovesamicol [(−)-oIV] as a selective vesicular acetylcholine transporter (VAChT) map** agent. (−)-[125I]oIV exhibited significant accumulation (about 2.8% of...
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Article
Local delivery of 131I-MIBG to treat peritoneal neuroblastoma
Internal radiotherapy involving systemic administration of iodine-131 metaiodobenzylguanidine (131I-MIBG) in neural crest tumours such as neuroblastoma has shown considerable success. Although peritoneal seeding ...
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Article
Reduction of 99mTc-sestamibi and 99mTc-tetrofosmin uptake in MRP-expressing breast cancer cells under hypoxic conditions is independent of MRP function
Hypoxia reduces the uptake of technetium-99m sestamibi (MIBI) in human cancer cell lines. In the current investigation, we attempted to identify the relationship between hypoxia-induced alteration of 99mTc-MIBI a...
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Article
Improved survival of mice bearing liver metastases of colon cancer cells treated with a combination of radioimmunotherapy and antiangiogenic therapy
We attempted to determine whether the combined regimen of radioimmunotherapy (RIT) and antiangiogenic therapy would favorably affect the survival of animals bearing liver metastases of colon cancer cells. Dail...
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Article
In vitro detection of mdr1 mRNA in murine leukemia cells with 111In-labeled oligonucleotide
The feasibility of intracellular mdr1 mRNA expression detection with radiolabeled antisense oligonucleotide (ODN) was investigated in the murine leukemia cell line, P388/S, and its subclonal, adriamycin-resistant...
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Article
99mTc-sestamibi to monitor treatment with antisense oligodeoxynucleotide complementary to MRP mRNA in human breast cancer cells
Technetium-99m sestamibi (MIBI) has been utilized to evaluate multi-drug resistance (MDR) phenomenon of malignant tumors and to predict chemotherapeutic effects on them. The current investigation examined the ...
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Article
Synthesis and evaluation of vesamicol analog (-)-o-[11C]methylvesamicol as a PET ligand for vesicular acetylcholine transporter
(-)-o-Methylvesamicol ((-)-OMV) exhibitedin vitro a high affinity for vesicular acetylcholine transporter (VAChT) (Ki, 6.7 nM) and a relatively low affinity for sigmai receptor (Ki, 33.7 nM). We prepared (-)-[11C...
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Article
Usefulness of competitive inhibitors of protein binding for improving the pharmacokinetics of 186Re-MAG3-conjugated bisphosphonate (186Re-MAG3-HBP), an agent for treatment of painful bone metastases
We have developed a 186Re-mercaptoacetylglycylglycylglycine complex-conjugated bisphosphonate (186Re-MAG3-HBP) for the treatment of painful bone metastases. We assumed competitive inhibitors of protein binding to...
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Article
Preparation and evaluation of 186/188Re-labeled antibody (A7) for radioimmunotherapy with rhenium(I) tricarbonyl core as a chelate site
Rhenium is one of the most valuable elements for internal radiotherapy because 186Re and 188Re have favorable physical characteristics. However, there are problems when proteins such as antibodies are used as car...
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Article
Open AccessDevelopment and evaluation of a novel radioiodinated vesamicol analog as a sigma receptor imaging agent
Sigma receptors are highly expressed in human tumors and should be appropriate targets for develo** tumor imaging agents. Previously, we synthesized a vesamicol analog, (+)-2-[4-(4-iodophenyl)piperidino]cycl...
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Article
Open AccessEffect of postconditioning on dynamic expression of tenascin-C and left ventricular remodeling after myocardial ischemia and reperfusion
Tenascin-C (TNC), an extracellular matrix glycoprotein, is expressed transiently in distinct areas in association with active tissue remodeling. This study aimed to explore how ischemic postconditioning (PC) a...
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Article
Open AccessCorrelation between apoptosis and left ventricular remodeling in subacute phase of myocardial ischemia and reperfusion
To investigate whether an apoptotic process demonstrated by 99mTc-annexin-V (99mTc-AV) uptake correlates with left ventricular remodeling (LVR) after myocardial infarction, we assessed 99mTc-AV uptake in rat mode...
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Article
Synthesis and evaluation of a new vesamicol analog o-[11C]methyl-trans-decalinvesamicol as a PET ligand for the vesicular acetylcholine transporter
We focused on the vesicle acetyl choline transporter (VAChT) as target for early diagnosis of Alzheimer’s diseases because the dysfunction of the cholinergic nervous system is closely associated with the sympt...
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Article
Simultaneous acquisition of 99mTc- and 123I-labeled radiotracers using a preclinical SPECT scanner with CZT detectors
Simultaneous acquisition of 99mTc and 123I was evaluated using a preclinical SPECT scanner with cadmium zinc telluride (CZT)-based detectors.
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Article
Quantification of Myocardial Perfusion Defect Size in Rats: Comparison between Quantitative Perfusion SPECT and Autoradiography
Ultra-high resolution single-photon emission computed tomography (SPECT) system, using multiple pinhole collimators, has been applied to the imaging of small rodents. We aimed to compare the myocardial infarct...
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Article
Fundamental study of radiogallium-labeled aspartic acid peptides introducing octreotate derivatives
Somatostatin receptors are highly expressed in neuroendocrine tumors, and many radiolabeled somatostatin analogs for diagnosis and treatment have been developed. To simultaneously detect not only primary cance...
