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Article
Enhancing the Hydrophobicity and Surface Roughness of Synthesized PVDF Membrane Using Evaporation and Non-solvent-Induced Phase Separation
This study focuses on the synthesis of a PVDF membrane using DMAc as the solvent through a combination of evaporation-induced phase separation (EIPS) and non solvent-induced phase separation (NIPS) techniques....
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Article
Open AccessAssessing the effectiveness of Interleukin-2 therapy in experimental type 1 diabetes
Much focus of immunotherapy for type 1 diabetes (T1D) has been devoted on selectively boosting regulatory T (Treg) cells using low dose IL-2 due to their constitutive expression of IL-2Rα, CD25. However, sever...
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Article
Open AccessThe Cdh5-CreERT2 transgene causes conditional Shb gene deletion in hematopoietic cells with consequences for immune cell responses to tumors
The tamoxifen-responsive conditional Cdh5-CreERT2 is commonly used for endothelial cell specific conditional deletion of loxP-flanked gene sequences. To address the role of endothelial cell Shb gene for B16F10 me...
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Article
Open AccessOverexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis
Heparanase is an endo-glucuronidase that degrades heparan sulfate chains. The enzyme is expressed at a low level in normal organs; however, elevated expression of heparanase has been detected in several inflam...
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Article
Open AccessAmino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus
The PA N-terminal domain (PA-Nter) is essential for viral transcription and replication. Here we identified PA-Nter substitutions A37S, I61T, V63I and V100A in recently emerged avian influenza A viruses (IAVs)...
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Article
Open AccessA novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase
The RNA-dependent RNA polymerase of influenza A virus comprises conserved and independently-folded subdomains with defined functionalities. The N-terminal domain of the PA subunit (PAN) harbors the endonuclease f...
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Article
Simulation-Based Artificial Neural Network Predictive Control of BTX Dividing Wall Column
For the separation of ternary liquid mixture, use of dividing wall column is one of the nonconventional techniques in the field of liquid separation by thermal process. Benzene, toluene, and o-xylene have been se...
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Article
Open AccessInterleukin-35 administration counteracts established murine type 1 diabetes – possible involvement of regulatory T cells
The anti-inflammatory cytokine IL-35 is produced by regulatory T (Treg) cells to suppress autoimmune and inflammatory responses. The role of IL-35 in type 1 diabetes (T1D) remains to be answered. To elucidate ...
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Article
Open AccessConcomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice
Regulatory T (Treg) cells are characterized by the expression of CD4, CD25 and the intracellular Foxp3. However, these markers do not indicate whether Treg cells are thymic derived Treg (tTreg) cells or periph...