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  1. Article

    Open Access

    A case of lung adenocarcinoma harboring EGFR mutation and EML4-ALKfusion gene

    Lung cancer is the leading cause of cancer-related death worldwide. Epidermal growth factor receptor (EGFR) - tyrosine kinase inhibitor (TKI) is used for the patients with EGFR-mutant lung cancer. Recently, phase...

    Hisashi Tanaka, Akihito Hayashi, Takeshi Morimoto, Kageaki Taima in BMC Cancer (2012)

  2. Article

    Open Access

    A single-arm phase II study of nab-paclitaxel for patients with chemorefractory non-small cell lung cancer

    We aimed to evaluate the efficacy and safety of nab-paclitaxel in patients with refractory advanced non-small cell lung cancer who failed previous chemotherapy.

    Hisashi Tanaka, Kageaki Taima, Takeshi Morimoto, Yoshihito Tanaka in BMC Cancer (2017)

  3. Article

    Open Access

    A phase I study of afatinib for patients aged 75 or older with advanced non-small cell lung cancer harboring EGFR mutations

    This phase I trial was conducted to determine the maximum tolerated dose (MTD) and recommended dose of afatinib for phase II trial in elderly patients with advanced non-small cell lung cancer (NSCLC) harboring...

    Hisashi Tanaka, Kageaki Taima, Yoshihito Tanaka, Masamichi Itoga in Medical Oncology (2018)

  4. Article

    Open Access

    Real-world study of afatinib in first-line or re-challenge settings for patients with EGFR mutant non-small cell lung cancer

    Afatinib, a second-generation epidermal growth factor receptor (EGFR)—tyrosine kinase inhibitor (TKI) for mutant non-small cell lung cancer (NSCLC), was approved in Japan in 2014. This study evaluated clinical...

    Hisashi Tanaka, Kageaki Taima, Masamichi Itoga, Yoshiko Ishioka in Medical Oncology (2019)