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  1. No Access

    Article

    Coiled-coil domain containing 68 (CCDC68) demonstrates a tumor-suppressive role in pancreatic ductal adenocarcinoma

    Using integrative genomics and functional screening, we identified coiled-coil domain containing 68 (CCDC68) as a novel putative tumor suppressor gene (TSG) in pancreatic ductal adenocarcinoma (PDAC). CCDC68 alle...

    N Radulovich, L Leung, E Ibrahimov, R Navab, S Sakashita, C-Q Zhu, E Kaufman… in Oncogene (2015)

  2. Article

    Open Access

    Genotranscriptomic meta-analysis of the Polycomb gene CBX2 in human cancers: initial evidence of an oncogenic role

    Polycomb group (PcG) proteins are histone modifiers known to transcriptionally silence key tumour suppressor genes in multiple human cancers. The chromobox proteins (CBX2, 4, 6, 7, and 8) are critical componen...

    P-L Clermont, L Sun, F Crea, K L Thu, A Zhang, A Parolia… in British Journal of Cancer (2014)

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  3. No Access

    Article

    EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk

    In an effort to identify novel biallelically inactivated tumor suppressor genes (TSGs) in sporadic invasive and preinvasive non-small-cell lung cancer (NSCLC) genomes, we applied a comprehensive integrated mul...

    I M Wilson, E A Vucic, K S S Enfield, K L Thu, Y A Zhang, R Chari, W W Lockwood… in Oncogene (2014)

  4. No Access

    Article

    SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/β-catenin signaling

    Pancreatic cancer is among the top five deadliest cancers in developed countries. Better knowledge of the molecular mechanisms contributing to its tumorigenesis is imperative to improve patient prognosis. Iden...

    K L Thu, N Radulovich, D D Becker-Santos, L A Pikor, A Pusic, W W Lockwood… in Oncogene (2014)