34 Result(s)

Article

Transcription factor ATMIN facilitates chemoresistance in nasopharyngeal carcinoma

Despite that the docectaxel-cisplatin-5-fluorouracil (TPF) induction chemotherapy has greatly improved patients’ survival and became the first-line treatment for advanced nasopharyngeal carcinoma (NPC), not al...

Xue-Liang Fang, Qing-Jie Li, Jia-Yi Lin, Cheng-Long Huang… in Cell Death & Disease (2024)

Article

Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1

Tumor-derived exosomes and their contents promote cancer metastasis. Phosphoglycerate mutase 1 (PGAM1) is involved in various cancer-related processes. Nevertheless, the underlying mechanism of exosomal PGAM1 ...

Jun-qi Luo, Tao-wei Yang, Jun Wu, Hou-hua Lai, Li-bin Zou… in Cell Death & Disease (2023)

Article

HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells

Renal defects in maturity onset diabetes of the young 3 (MODY3) patients and Hnf1a^-/- mice suggest an involvement of HNF1A in kidney development and/or its function. Although numerous studies have leveraged on Hn...

Jun Wei Chan, Claire Wen Ying Neo, Soumita Ghosh, Hyungwon Choi… in Cell Death & Disease (2023)

Article

m⁵C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 mRNAs splicing and stabilization

The significance of 5-methylcytosine (m⁵C) methylation in human malignancies has become an increasing focus of investigation. Here, we show that m⁵C regulators including writers, readers and erasers, are predomin...

Ning Wang, Ri-xin Chen, Min-hua Deng, Wen-su Wei, Zhao-hui Zhou… in Cell Death & Disease (2023)

Article

Single cell epigenomic and transcriptomic analysis uncovers potential transcription factors regulating mitotic/meiotic switch

In order to reveal the complex mechanism governing the mitotic/meiotic switch in female germ cells at epigenomic and genomic levels, we examined the chromatin accessibility (scATAC-seq) and the transcriptional...

Fa-Li Zhang, Yan-Qin Feng, **g-Ya Wang, Ke-**n Zhu, Lu Wang… in Cell Death & Disease (2023)

Article

Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma

LINC00941 is a novel long noncoding RNA (lncRNA) and emerging as an important factor in cancer development. However, the exact function and relative regulatory mechanism of LINC00941 in carcinogenesis of esoph...

Jun-Tao Lu, Zhao-Yang Yan, Tong-**n Xu, Fan Zhao, Lei Liu, Fei Li… in Cell Death & Disease (2023)

Article

SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm

Splicing factor 3B subunit 4 (SF3B4) plays important functional roles not only in pre-mRNA splicing, but also in the regulation of transcription, translation, and cell signaling, and its dysregulation contribu...

Zhan Yang, Ya-Xuan Wang, **-Kun Wen, Hai-Tao Gao, Zhen-Wei Han… in Cell Death & Disease (2023)

Article

Correction: Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Wan-jun Yang, Rong-chang Cao, Wang **ao, **ao-lou Zhang, Hao Xu… in Cell Death & Disease (2022)

Article

Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Noninflammatory clearance of dying cells by professional phagocytes, termed efferocytosis, is fundamental in both homeostasis and inflammatory fibrosis disease but has not been confirmed to occur in chronic pa...

Wan-jun Yang, Rong-chang Cao, Wang **ao, **ao-lou Zhang, Hao Xu… in Cell Death & Disease (2022)

Article

Bone marrow mesenchymal stem cell-derived extracellular vesicles containing miR-181d protect rats against renal fibrosis by inhibiting KLF6 and the NF-κB signaling pathway

Recent studies have investigated the ability of extracellular vesicles (EVs) in regulating neighboring cells by transferring signaling molecules, such as microRNAs (miRs) in renal fibrosis. EVs released by bon...

Shi-Jun Wang, Zhen-Zhen Qiu, Fu-Wei Chen, An-Li Mao, Jun-Chao Bai… in Cell Death & Disease (2022)

Article

Landscape of the RBD-specific IgG, IgM, and IgA responses triggered by the inactivated virus vaccine against the Omicron variant

Jun-biao Xue, Dan-yun Lai, He-wei Jiang, Huan Qi, Shu-juan Guo… in Cell Discovery (2022)

Article

EIF4A3-induced circular RNA PRKAR1B promotes osteosarcoma progression by miR-361-3p-mediated induction of FZD4 expression

Emerging evidence indicates that circRNAs are broadly expressed in osteosarcoma (OS) cells and play a crucial role in OS progression. Recently, cancer-specific circRNA circPRKAR1B has been identified by high-t...

Zhen-hua Feng, Lin Zheng, Teng Yao, Si-yue Tao, **ao-an Wei… in Cell Death & Disease (2021)

Article

GOLPH3/CKAP4 promotes metastasis and tumorigenicity by enhancing the secretion of exosomal WNT3A in non-small-cell lung cancer

Cancer metastasis is the main cause of mortality associated with non-small-cell lung cancer (NSCLC), accounting for up to 70% of deaths among patients. The mechanisms underlying distal metastasis remain largel...

Jun-Wei Song, **g Zhu, **ng-Xuan Wu, Ting Tu, **g-Qiang Huang… in Cell Death & Disease (2021)

Article

Systematic profiling of SARS-CoV-2-specific IgG responses elicited by an inactivated virus vaccine identifies peptides and proteins for predicting vaccination efficacy

One of the best ways to control COVID-19 is vaccination. Among the various SARS-CoV-2 vaccines, inactivated virus vaccines have been widely applied in China and many other countries. To understand the underlyi...

Ming-Liang Ma, Da-Wei Shi, Yang Li, Wei Hong, Dan-Yun Lai, Jun-Biao Xue… in Cell Discovery (2021)

Article

Notch3 inhibits cell proliferation and tumorigenesis and predicts better prognosis in breast cancer through transactivating PTEN

Notch receptors (Notch1–4) play critical roles in tumorigenesis and metastasis of malignant tumors, including breast cancer. Although abnormal Notch activation is related to various tumors, the importance of s...

Yong-Qu Zhang, Yuan-Ke Liang, Yang Wu, Min Chen, Wei-Ling Chen… in Cell Death & Disease (2021)

Article

MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity

MLL3 is a histone H3K4 methyltransferase that is frequently mutated in cancer, but the underlying molecular mechanisms remain elusive. Here, we found that MLL3 depletion by CRISPR/sgRNA significantly enhanced cel...

Jun-Yi Zheng, Chen-Yu Wang, Chuan Gao, Qiong **ao, Cheng-Wei Huang… in Cell Death & Disease (2021)

Article

Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells

Expression of kinesin family member 18B (KIF18B), an ATPase with key roles in cell division, is deregulated in many cancers, but its involvement in prostate cancer (PCa) is unclear. Here, we investigated the e...

Yu-Peng Wu, Zhi-Bin Ke, Wen-Cai Zheng, Ye-Hui Chen, Jun-Ming Zhu… in Cell Death & Disease (2021)

Article

EMC6 regulates acinar apoptosis via APAF1 in acute and chronic pancreatitis

Treatment of acute pancreatitis (AP) and chronic pancreatitis (CP) remains problematic due to a lack of knowledge about disease-specific regulatory targets and mechanisms. The purpose of this study was to scre...

Jie-hui Tan, Rong-chang Cao, Lei Zhou, Zhi-tao Zhou, Huo-ji Chen… in Cell Death & Disease (2020)

Article

Correction: miR-1260b, mediated by YY1, activates KIT signaling by targeting SOCS6 to regulate cell proliferation and apoptosis in NSCLC

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Yang **a, Ke Wei, Feng-Ming Yang, Liu-Qing Hu, Chun-Feng Pan… in Cell Death & Disease (2020)