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  1. Article

    Open Access

    Protein function prediction through multi-view multi-label latent tensor reconstruction

    In last two decades, the use of high-throughput sequencing technologies has accelerated the pace of discovery of proteins. However, due to the time and resource limitations of rigorous experimental functional ...

    Robert Ebo Armah-Sekum, Sandor Szedmak, Juho Rousu in BMC Bioinformatics (2024)

  2. No Access

    Article

    Systematic classification of unknown metabolites using high-resolution fragmentation mass spectra

    Metabolomics using nontargeted tandem mass spectrometry can detect thousands of molecules in a biological sample. However, structural molecule annotation is limited to structures present in libraries or databa...

    Kai Dührkop, Louis-Félix Nothias, Markus Fleischauer, Raphael Reher in Nature Biotechnology (2021)

  3. No Access

    Article

    SIRIUS 4: a rapid tool for turning tandem mass spectra into metabolite structure information

    Mass spectrometry is a predominant experimental technique in metabolomics and related fields, but metabolite structural elucidation remains highly challenging. We report SIRIUS 4 (https://bio.informatik.uni-jena....

    Kai Dührkop, Markus Fleischauer, Marcus Ludwig, Alexander A. Aksenov in Nature Methods (2019)

  4. Article

    Open Access

    Selected proceedings of Machine Learning in Systems Biology: MLSB 2016

    Aalt D. J. van Dijk, Harri Lähdesmäki, Dick de Ridder, Juho Rousu in BMC Bioinformatics (2016)

  5. Article

    Open Access

    Inferring branching pathways in genome-scale metabolic networks

    A central problem in computational metabolic modelling is how to find biochemically plausible pathways between metabolites in a metabolic network. Two general, complementary frameworks have been utilized to fi...

    Esa Pitkänen, Paula Jouhten, Juho Rousu in BMC Systems Biology (2009)

  6. Article

    Open Access

    An analytic and systematic framework for estimating metabolic flux ratios from 13C tracer experiments

    Metabolic fluxes provide invaluable insight on the integrated response of a cell to environmental stimuli or genetic modifications. Current computational methods for estimating the metabolic fluxes from 13C isoto...

    Ari Rantanen, Juho Rousu, Paula Jouhten, Nicola Zamboni in BMC Bioinformatics (2008)

  7. Article

    Open Access

    Probabilistic modeling and machine learning in structural and systems biology

    This supplement contains extended versions of a selected subset of papers presented at the workshop PMSB 2007, Probabilistic Modeling and Machine Learning in Structural and Systems Biology, Tuusula, Finland, f...

    Samuel Kaski, Juho Rousu, Esko Ukkonen in BMC Bioinformatics (2007)