9 Result(s)
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Article
Juan Shen
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessCold-induced FOXO1 nuclear transport aids cold survival and tissue storage
Cold-induced injuries severely limit opportunities and outcomes of hypothermic therapies and organ preservation, calling for better understanding of cold adaptation. Here, by surveying cold-altered chromatin a...
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Open AccessDefects in the cell wall and its deposition caused by loss-of-function of three RLKs alter root hydrotropism in Arabidopsis thaliana
Root tips can sense moisture gradients and grow into environments with higher water potential. This process is called root hydrotropism. Here, we report three closely related receptor-like kinases (RLKs) that ...
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Article
Open AccessIntrinsically disordered CsoS2 acts as a general molecular thread for α-carboxysome shell assembly
Carboxysomes are a paradigm of self-assembling proteinaceous organelles found in nature, offering compartmentalisation of enzymes and pathways to enhance carbon fixation. In α-carboxysomes, the disordered link...
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Article
Open AccessSulindac selectively induces autophagic apoptosis of GABAergic neurons and alters motor behaviour in zebrafish
Nonsteroidal anti-inflammatory drugs compose one of the most widely used classes of medications, but the risks for early development remain controversial, especially in the nervous system. Here, we utilized ze...
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Open AccessMolecular architecture and conservation of an immature human endogenous retrovirus
The human endogenous retrovirus K (HERV-K) is the most recently acquired endogenous retrovirus in the human genome and is activated and expressed in many cancers and amyotrophic lateral sclerosis. We present t...
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Open AccessConstruction and validation of web-based nomograms for detecting and prognosticating in prostate adenocarcinoma with bone metastasis
Bone metastasis (BM) is one of the most common sites of metastasis in prostate adenocarcinoma (PA). PA with BM can significantly diminish patients’ quality of life and result in a poor prognosis. The objective...
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Open AccessStructure and activity of particulate methane monooxygenase arrays in methanotrophs
Methane-oxidizing bacteria play a central role in greenhouse gas mitigation and have potential applications in biomanufacturing. Their primary metabolic enzyme, particulate methane monooxygenase (pMMO), is hou...
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Article
Open AccessNMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury
Damage-associated molecular patterns (DAMP) trigger innate immune response and exacerbate inflammation to combat infection and cellular damage. Identifying DAMPs and revealing their functions are thus of cruci...
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Open AccessPerformance of genetic risk factors in prediction of trichloroethylene induced hypersensitivity syndrome
Trichloroethylene induced hypersensitivity syndrome is dose-independent and potentially life threatening disease, which has become one of the serious occupational health issues and requires intensive treatment...
