9 Result(s)
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Article
Ju-fang Huang
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Article
Role of CAST-Drp1 Pathway in Retinal Neuron-Regulated Necrosis in Experimental Glaucoma
Numerous studies have indicated that excitatory amino acid toxicity, such as glutamate toxicity, is involved in glaucoma. In addition, excessive glutamate can lead to an intracellular calcium overload, resulti...
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Article
The Toxic Effect of ALLN on Primary Rat Retinal Neurons
N-acetyl-leucyl-leucyl-norleucinal (ALLN), an inhibitor of proteasomes and calpain, is widely used to reduce proteasomes or calpain-mediated cell death in rodents. However, ALLN is toxic ...
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Article
Open AccessStudy on establishment and mechanics application of finite element model of bovine eye
Glaucoma mainly induced by increased intraocular pressure (IOP), it was believed that the pressure that wall of eyeball withstands were determined by material properties of the tissue and stereoscopic geometry...
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Open AccessReceptor interacting protein 3-induced RGC-5 cell necroptosis following oxygen glucose deprivation
Necroptosis is a type of regulated form of cell death that has been implicated in the pathogenesis of various diseases. Receptor-interacting protein 3 (RIP3), a member of the RIP family of proteins, has been r...
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Open AccessThe effect and underlying mechanism of Timosaponin B-II on RGC-5 necroptosis induced by hydrogen peroxide
Necroptosis is an important mode of cell death, which is due to oxidant stress accumulation. Our previous study indicated that oxidant stresses could be reduced by Timosaponin B-II (TBII), a kind of Chinese herb
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Open AccessCalpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure
RIP3 (Receptor-interacting protein 3) pathway was mainly described as the molecular mechanism of necroptosis (programmed necrosis). But recently, non-RIP3 pathways were found to mediate necroptosis. We deliber...
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Open AccessDifferential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response
Receptor-interacting protein 3 (RIP3), a member of RIP family proteins, has been shown to participate in programmed necrosis or necroptosis in cell biology studies. Evidence suggests that necroptosis may be a ...
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Article
Open AccessElevation of soluble major histocompatibility complex class I related chain A protein in malignant and infectious diseases in Chinese patients
Elevation of soluble major histocompatibility complex class I chain-related gene A (sMICA) products in serum has been linked to tissue/organ transplantation, autoimmune diseases and some malignant disorders. C...
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Open AccessTimosaponin-BII inhibits the up-regulation of BACE1 induced by Ferric Chloride in rat retina
Our previous studies indicated that oxidative stress up-regulated the expression of β-amyloid precursor protein cleavage enzyme-1 (BACE1) in rat retina. Pharmacological reports have shown Timosaponin-BII, a pu...
