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Transcriptional repression of Bmp2 by p21Waf1/Cip1 links quiescence to neural stem cell maintenance
The self renewal and long-term maintenance of neural stem cells (NSCs) is related to how quickly they pass through the cell cycle. Here the authors describe a new role for the cyclin-dependent kinase inhibitor...
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Article
Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone
Notch signaling is essential for the maintenance of adult neural stem cells in vivo. Here, Andreu-Agulló and colleagues show that PEDF, released from endothelial cells, enhances Notch signaling in the mouse subep...