3 Result(s)
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Article
Jonathan M. Ungania
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Article
Open AccessMitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity
Hypometabolism tied to mitochondrial dysfunction occurs in the aging brain and in neurodegenerative disorders, including in Alzheimer’s disease, in Down syndrome, and in mouse models of these conditions. We ha...
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Isolation of mitochondria-derived mitovesicles and subpopulations of microvesicles and exosomes from brain tissues
Extracellular vesicles (EVs) are nanoscale vesicles secreted into the extracellular space by all cell types, including neurons and astrocytes in the brain. EVs play pivotal roles in physiological and pathophys...
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Open AccessCocaine Modulates the Neuronal Endosomal System and Extracellular Vesicles in a Sex-Dependent Manner
In multiple neurodevelopmental and neurodegenerative disorders, endosomal changes correlate with changes in exosomes. We examined this linkage in the brain of mice that received cocaine injections for two week...
