14 Result(s)
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Article
John J. Park
English
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Article
Spontaneous ureterocolic fistula secondary to diverticulitis: report of a case and review of literature
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Management of Anastomotic Leak: Lessons Learned from a Large Colon and Rectal Surgery Training Program
Anastomotic leak is a dreaded surgical complication that can lead to significant morbidity and mortality. Despite its prevalence, there is no consensus on the management of anastomotic leak. This study aimed t...
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Endoscopic control of enterocutaneous fistula by dual intussuscepting stent technique
Large high-output enterocutaneous fistulas pose great difficulties, especially in the setting of recent surgery and compromised skin integrity.
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The Kalām Cosmological Argument, the Big Bang, and Atheism
While there has been much work on cosmological arguments, novel objections will be presented against the modern day rendition of the Kalām cosmological argument as standardly articulated by William Lane Craig....
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Robotic Site Adjusted Levator Transection for Carcinoma of the Rectum: A Modification of the Existing Cylindrical Abdominoperineal Resection for Eccentrically Located Tumors
Today, extralevator abdominoperineal resection is the standard of care for low rectal cancers with sphincter involvement or location precluding anastomosis. This procedure, while effective from an oncologic p...
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Robotic Surgery for Colon and Rectal Cancer: Current Status, Recent Advances, and Future Directions
The minimally invasive approach to colorectal cancers has been validated as providing oncologic outcomes comparable to open surgery. Current laparoscopic instrumentation, however, has its limitations especiall...
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Open AccessEfficacy of anti-PD-1 therapy in patients with melanoma brain metastases
There is limited data on the efficacy of anti-programmed death 1 (PD-1) antibodies in patients (pts) with melanoma brain metastasis (BM), particularly those which are symptomatic.
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Open AccessWhole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours
Uveal melanoma (UM) is the most common intraocular tumour in adults and despite surgical or radiation treatment of primary tumours, ~50% of patients progress to metastatic disease. Therapeutic options for meta...
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Open AccessImmunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults
Arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) derived lipids play key roles in initiating and resolving inflammation. Neuro-inflammation is thought to play a causal role in...
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Feasibility assessment of outpatient colorectal resections at a tertiary referral center
Enhanced Recovery After Surgery (ERAS) protocols, particularly when paired with advanced laparoscopy, have reduced recovery time following colorectal procedures. The aim of this study was to determine if lengt...
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Open AccessProtein kinase inhibitor responses in uveal melanoma reflects a diminished dependency on PKC-MAPK signaling
Uveal melanoma (UM) is a rare cancer arising from melanocytes in the uveal tract of the eye. Despite effective primary treatment, there is no approved therapy for metastatic UM and prognosis and survival remai...
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Open AccessA first-in-human phase 1 study of nofazinlimab, an anti-PD-1 antibody, in advanced solid tumors and in combination with regorafenib in metastatic colorectal cancer
We assessed nofazinlimab, an anti-PD-1 antibody, in solid tumors and combined with regorafenib in metastatic colorectal cancer (mCRC).
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Open AccessPKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma
Protein kinase C (PKC) is activated downstream of gain-of-function GNAQ or GNA11 (GNAQ/GNA11) mutations in over 90% of uveal melanoma (UM). Phase I clinical trials of PKC inhibitors have shown modest response rat...
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Confucian Meritocratic Democracy over Democracy for Minority Interests and Rights
In Western political philosophy, democracy is generally the dominant view regarding what the best form of government is, and this holds even in respect to promoting minority rights. However, I argue that there...
