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  1. Article

    Open Access

    TRAF2/3 deficient B cells resist DNA damage-induced apoptosis via NF-κB2/XIAP/cIAP2 axis and IAP antagonist sensitizes mutant lymphomas to chemotherapeutic drugs

    Deletion of TRAF2 or TRAF3 in B cells prolongs their survival. However, it remains unknown whether deletion of such factors affects B cells’ ability to tolerate DNA damage, which can be induced by chemotherapeuti...

    Monika Vashisht, Huaibin Ge, Jessy John, Harlie A. McKelvey… in Cell Death & Disease (2023)

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  2. Article

    Open Access

    Differential responses to immune checkpoint inhibitor dictated by pre-existing differential immune profiles in squamous cell carcinomas caused by same initial oncogenic drivers

    While immune checkpoint inhibitors (ICI) were approved for head and neck squamous cell carcinomas (HNSCCs), the response rate remains relatively low. Mechanisms underlying ICI unresponsiveness versus sensitivi...

    Samantha M. Y. Chen, Vince Popolizio… in Journal of Experimental & Clinical Cancer … (2022)

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