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  1. Article

    Open Access

    Targeting fibroblast growth factor receptors to combat aggressive ependymoma

    Ependymomas (EPN) are central nervous system tumors comprising both aggressive and more benign molecular subtypes. However, therapy of the high-risk subtypes posterior fossa group A (PF-A) and supratentorial R...

    Daniela Lötsch, Dominik Kirchhofer, Bernhard Englinger, Li Jiang… in Acta Neuropathologica (2021)

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    Article

    Heterogeneity within the PF-EPN-B ependymoma subgroup

    Posterior fossa ependymoma comprise three distinct molecular variants, termed PF-EPN-A (PFA), PF-EPN-B (PFB), and PF-EPN-SE (subependymoma). Clinically, they are very disparate and PFB tumors are currently bei...

    Florence M. G. Cavalli, Jens-Martin Hübner, Tanvi Sharma… in Acta Neuropathologica (2018)

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    Article

    Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

    Of nine ependymoma molecular groups detected by DNA methylation profiling, the posterior fossa type A (PFA) is most prevalent. We used DNA methylation profiling to look for further molecular heterogeneity amon...

    Kristian W. Pajtler, Ji Wen, Martin Sill, Tong Lin, Wilda Orisme… in Acta Neuropathologica (2018)