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  1. Article

    Open Access

    Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition

    Here we demonstrate for the first time that targeted inhibition of nuclear exporter protein exportin 1 (XPO1) also known as chromosome maintenance region 1 (CRM1) by Selective Inhibitor of Nuclear Export (SINE...

    Asfar S. Azmi, Irfana Muqbil, Jack Wu, Amro Aboukameel… in Scientific Reports (2015)

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  2. No Access

    Article

    Splicing of mouse p53 pre-mRNA does not always follow the “first come, first served” principle and may be influenced by cisplatin treatment and serum starvation

    Transcription of a pre-mRNA in eukaryotic cells elongates from the 5′ to the 3′ end, but intron removal during a pre-mRNA splicing does not always proceed in this orientation. In this study, we identified eigh...

    Min Yang, Jack Wu, Si-hung Wu, An-ding Bi, D. Joshua Liao in Molecular Biology Reports (2012)

  3. Article

    Open Access

    An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals

    MI-319 is a synthetic small molecule designed to target the MDM2-P53 interaction. It is closely related to MDM2 antagonists MI-219 and Nutlin-3 in terms of the expected working mechanisms. The purpose of this ...

    Ramzi M Mohammad, Jack Wu, Asfar S Azmi, Amro Aboukameel, Angela Sosin… in Molecular Cancer (2009)

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  4. No Access

    Article

    Expression profile of microRNAs in c-Myc induced mouse mammary tumors

    c-Myc is a transcription factor overexpression of which induces mammary cancer in transgenic mice. To explore whether certain microRNAs (mirRNA) mediate c-Myc induced mammary carcinogenesis, we studied mirRNA ...

    Yuan Sun, Jack Wu, Si-hung Wu, Archana Thakur… in Breast Cancer Research and Treatment (2009)

  5. No Access

    Article

    Identification of the cyclin D1b mRNA variant in mouse

    Cyclin D1 plays a key regulatory role during the G1 phase of the cell cycle and its gene is amplified and over-expressed in many cancers. The cyclin D1b mRNA variant was established in human cells and recent f...

    Jack Wu, Si-hung Wu, Aliccia Bollig, Archana Thakur… in Molecular Biology Reports (2009)