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Genetic alterations and their clinical implications in older patients with acute myeloid leukemia

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  1. Article

    Open Access

    Clinico-biological significance of suppressor of cytokine signaling 1 expression in acute myeloid leukemia

    Suppressor of cytokine signaling 1 (SOCS1) protein, which encodes a member of signal transducers and activators of transcription-induced inhibitors, takes part in a negative regulation of cytokine signaling. T...

    H-A Hou, J-W Lu, T-Y Lin, C-H Tsai, W-C Chou, C-C Lin, Y-Y Kuo in Blood Cancer Journal (2017)

  2. Article

    Open Access

    TP53 mutations in de novo acute myeloid leukemia patients: longitudinal follow-ups show the mutation is stable during disease evolution

    The TP53 mutation is frequently detected in acute myeloid leukemia (AML) patients with complex karyotype (CK), but the stability of this mutation during the clinical course remains unclear. In this study, TP53 mu...

    H-A Hou, W-C Chou, Y-Y Kuo, C-Y Liu, L-I Lin, M-H Tseng, Y-C Chiang in Blood Cancer Journal (2015)

  3. Article

    Open Access

    Dynamics of ASXL1 mutation and other associated genetic alterations during disease progression in patients with primary myelodysplastic syndrome

    Recently, mutations of the additional sex comb-like 1 (ASXL1) gene were identified in patients with myelodysplastic syndrome (MDS), but the interaction of this mutation with other genetic alterations and its dyna...

    T-C Chen, H-A Hou, W-C Chou, J-L Tang, Y-Y Kuo, C-Y Chen, M-H Tseng in Blood Cancer Journal (2014)

  4. Article

    Open Access

    Distinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia

    Aberrant activation of Wnt signalling through hypermethylation of Wnt inhibitor genes is involved in several human malignancies, including acute myeloid leukaemia (AML). It remains unclear whether hypermethyla...

    H-A Hou, Y-Y Kuo, C-Y Liu, M C Lee, J-L Tang, C-Y Chen in British Journal of Cancer (2011)

  5. Article

    Open Access

    High bone marrow angiopoietin-1 expression is an independent poor prognostic factor for survival in patients with myelodysplastic syndromes

    Angiogenic factors have an essential role in normal and pathologic angiogenesis. However, the clinical implication of angiogenic factor expression in myelodysplastic syndromes (MDS) remains unclear.

    C-L Cheng, H-A Hou, J-Y Jhuang, C-W Lin, C-Y Chen, J-L Tang in British Journal of Cancer (2011)

  6. Article

    Erratum: A novel fluorescence-based multiplex PCR assay for rapid simultaneous detection of CEBPA mutations and NPM mutations in patients with acute myeloid leukemias

    Correction to: Leukemia (2007) 20, 1899–1903. doi:10.1038/sj.leu.2404331 Since the publication of the above paper, the authors have noticed an error in the sequence of primers used for TAD1, TAD2 and bZIP ampl...

    L-I Lin, T-C Lin, W-C Chou, J-L Tang, D-T Lin, H-F Tien in Leukemia (2007)