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Additional treatment with 2-Chloro-2-Deoxyadenosine during consolidation in children with high-risk acute myeloid leukemia does not improve survival
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Favorable outcome in infants with AML after intensive first- and second-line treatment: an AML-BFM study group report
Infants <1 year of age have a high prevalence of prognostically unfavorable leukemias and a presumed susceptibility to treatment-related toxicities. A total of 125 infants with acute myeloid leukemia (AML) wer...
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Long-term results of national treatment trials in childhood acute lymphoblastic leukaemia in several Middle/East European countries
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History of treatment and long-term outcome in children with acute lymphoblastic leukemia in the Czech Republic
PURPOSE: Treatment of childhood acute lymphoblastic leukemia (ALL) was unified in the year 1986 in the Czech Republic using BFM protocols. PATIENTS AND METHODS: Children were treated in 10 and later on in 8 ce...
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Article
Hematopoietic stem cell transplantation for advanced myelodysplastic syndrome in children: results of the EWOG-MDS 98 study
We report on the outcome of children with advanced primary myelodysplastic syndrome (MDS) transplanted from an HLA-matched sibling (MSD) or an unrelated donor (UD) following a preparative regimen with busulfan...
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Article
Mutation analysis of Son of Sevenless in juvenile myelomonocytic leukemia
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Second allogeneic hematopoietic stem cell transplantation (HSCT) results in outcome similar to that of first HSCT for patients with juvenile myelomonocytic leukemia
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Article
JAK2 V617F mutation is a rare event in juvenile myelomonocytic leukemia
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Article
Donor leukocyte infusion after hematopoietic stem cell transplantation in patients with juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is a clonal myeloproliferative disorder of early childhood. In all, 21 patients with JMML who received donor leukocyte infusion (DLI) after allogeneic hematopoietic stem...
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Article
Correlation of CD33 with poorer prognosis in childhood ALL implicates a potential of anti-CD33 frontline therapy
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Article
The International Prognostic Scoring System (IPSS) for childhood myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML)
The International Prognostic Scoring System (IPSS) for myelodysplastic syndrome (MDS) is based upon weighted data on bone marrow (BM) blast percentage, cytopenia, and cytogenetics, separating patients into fou...
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Article
Real-time quantitative PCR detection of WT1 gene expression in children with AML: prognostic significance, correlation with disease status and residual disease detection by flow cytometry
The clinical significance of WT1 gene expression at diagnosis and during therapy of AML has not yet been resolved. We analysed WT1 expression at presentation in an unselected group of 47 childhood AML patients...
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Article
Acute lymphoblastic leukemia incidence during socioeconomic transition: selective increase in children from 1 to 4 years
Pre-school acute lymphoblastic leukemia (ALL) peak is consistent in developed but not in develo** countries and its magnitude apparently correlates with the socioeconomic status. A population-based study des...
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Article
Significantly lower relapse rate for TEL/AML1-positive ALL
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Are we ready to curtail testing TEL/AML1 fusion?
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Myelodysplastic syndrome, juvenile myelomonocytic leukemia, and acute myeloid leukemia associated with complete or partial monosomy 7
We reviewed the clinical features, treatment, and outcome of 100 children with myelodysplastic syndrome (MDS), juvenile myelomonocytic leukemia (JMML), and acute myeloid leukemia (AML) associated with complete...
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Article
TEL/AML1 positivity in childhood ALL: average or better prognosis?
The presence of TEL/AML1 fusion gene in childhood acute lymphoblastic leukaemia (ALL) defines a subgroup of patients with better than average outcome. However, the prognostic significance of this aberration ha...
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Article
Simple competitive two-step RT-PCR assay to monitor minimal residual disease in CML patients after bone marrow transplantation
Quantitative reverse transcription-polymerase chain reaction (Q-RT-PCR) assessing the amount of transcripts of the BCR/ABL gene, the molecular marker of chronic myeloid leukemia (CML), is the only method sensi...
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Article
Aberrant expression of KOR-SA3544 antigen in childhood acute lymphoblastic leukemia predicts TEL-AML1 negativity
The antigen KOR-SA3544 is physiologically expressed exclusively on granulocytes. Aberrant expression of KOR-SA3544 has been invariably found in BCR/ABL-positive acute lymphoblastic leukemia (ALL) and in some B...
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Impact of TEL/AML1-positive patients on age distribution of childhood acute lymphoblastic leukemia in Czech Republic