45 Result(s)

Article

Additional treatment with 2-Chloro-2-Deoxyadenosine during consolidation in children with high-risk acute myeloid leukemia does not improve survival

U Creutzig, M N Dworzak, M Zimmermann, J-P Bourquin, B Gruhn, G Fleischhack… in Leukemia (2015)

Article

Favorable outcome in infants with AML after intensive first- and second-line treatment: an AML-BFM study group report

Infants <1 year of age have a high prevalence of prognostically unfavorable leukemias and a presumed susceptibility to treatment-related toxicities. A total of 125 infants with acute myeloid leukemia (AML) wer...

U Creutzig, M Zimmermann, J-P Bourquin, M N Dworzak, B Kremens, T Lehrnbecher… in Leukemia (2012)

Article

History of treatment and long-term outcome in children with acute lymphoblastic leukemia in the Czech Republic

PURPOSE: Treatment of childhood acute lymphoblastic leukemia (ALL) was unified in the year 1986 in the Czech Republic using BFM protocols. PATIENTS AND METHODS: Children were treated in 10 and later on in 8 ce...

J. Starý, V. Mihál, P. Smíšek, B. Blažek… in memo - Magazine of European Medical Oncolo… (2011)

Article

Signature profiles of CMV-specific T-cells in patients with CMV reactivation after hematopoietic SCT

Depletion of cellular immunity as a consequence of conditioning before allogeneic hematopoietic SCT (HSCT) frequently results in CMV reactivation, which may in turn lead to life-threatening infections and requ...

L Król, J Stuchlý, P Hubáček, P Keslová, P Sedláček, J Starý… in Bone Marrow Transplantation (2011)

Article

Hematopoietic stem cell transplantation for advanced myelodysplastic syndrome in children: results of the EWOG-MDS 98 study

We report on the outcome of children with advanced primary myelodysplastic syndrome (MDS) transplanted from an HLA-matched sibling (MSD) or an unrelated donor (UD) following a preparative regimen with busulfan...

B Strahm, P Nöllke, M Zecca, E T Korthof, M Bierings, I Furlan, P Sedlacek… in Leukemia (2011)

Article

Mutation analysis of Son of Sevenless in juvenile myelomonocytic leukemia

C P Kratz, C M Niemeyer, C Thomas, S Bauhuber, V Matejas, E Bergsträsser… in Leukemia (2007)

Article

Second allogeneic hematopoietic stem cell transplantation (HSCT) results in outcome similar to that of first HSCT for patients with juvenile myelomonocytic leukemia

A Yoshimi, M Mohamed, M Bierings, C Urban, E Korthof, M Zecca, K-W Sykora… in Leukemia (2007)

Article

JAK2 V617F mutation is a rare event in juvenile myelomonocytic leukemia

M Zecca, G Bergamaschi, C Kratz, E Bergsträßer, C Danesino, P De Filippi… in Leukemia (2007)

Article

Low mortality of children undergoing hematopoietic stem cell transplantation from 7 to 8/10 human leukocyte antigen allele-matched unrelated donors with the use of antithymocyte globulin

Human leukocyte antigen (HLA)-matched sibling donor hematopoietic stem cell transplantation (HSCT) is available for only approximately 30% patients needing HSCT. Use of alternative donors is associated with a ...

P Sedláček, R Formánková, P Keslová, L Šrámková, P Hubáček… in Bone Marrow Transplantation (2006)

Article

Donor leukocyte infusion after hematopoietic stem cell transplantation in patients with juvenile myelomonocytic leukemia

Juvenile myelomonocytic leukemia (JMML) is a clonal myeloproliferative disorder of early childhood. In all, 21 patients with JMML who received donor leukocyte infusion (DLI) after allogeneic hematopoietic stem...

A Yoshimi, P Bader, S Matthes-Martin, J Starý, P Sedlacek, U Duffner… in Leukemia (2005)

Article

Correlation of CD33 with poorer prognosis in childhood ALL implicates a potential of anti-CD33 frontline therapy

E Mejstříková, T Kalina, J Trka, J Starý, O Hrušák in Leukemia (2005)

Article

Stem cell transplantation for aplastic anemia and myelodysplastic syndrome

Stem cell transplantation (SCT) from a histocompatible sibling is treatment of choice for severe aplastic anemia. Survival rates have been reported to be as high as 90% for children. Immunosuppressive therapy ...

J Starý, F Locatelli, C M Niemeyer in Bone Marrow Transplantation (2005)

Article

The International Prognostic Scoring System (IPSS) for childhood myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML)

The International Prognostic Scoring System (IPSS) for myelodysplastic syndrome (MDS) is based upon weighted data on bone marrow (BM) blast percentage, cytopenia, and cytogenetics, separating patients into fou...

H Hasle, I Baumann, E Bergsträsser, S Fenu, A Fischer, G Kardos, G Kerndrup… in Leukemia (2004)

Article

Real-time quantitative PCR detection of WT1 gene expression in children with AML: prognostic significance, correlation with disease status and residual disease detection by flow cytometry

The clinical significance of WT1 gene expression at diagnosis and during therapy of AML has not yet been resolved. We analysed WT1 expression at presentation in an unselected group of 47 childhood AML patients...

J Trka, M Kalinová, O Hrušák, J Zuna, O Krejčí, J Madžo, P Sedláček, V Vávra… in Leukemia (2002)

Article

Acute lymphoblastic leukemia incidence during socioeconomic transition: selective increase in children from 1 to 4 years

Pre-school acute lymphoblastic leukemia (ALL) peak is consistent in developed but not in develo** countries and its magnitude apparently correlates with the socioeconomic status. A population-based study des...

O Hrušák, J Trka, J Zuna, A Poloučková, T Kalina, J Starý in Leukemia (2002)

Article

Detailed monitoring of hematopoietic chimerism in a child treated by adoptive immunotherapy for high risk of relapse after BMT for acute myeloid leukemia

We report a case of a 13-year-old boy who was transplanted for relapse of acute myeloid leukemia (AML). A detailed study of hematopoietic chimerism was performed using polymerase chain reaction (PCR) of variab...

R Formánková, L Honzátková, Z Sieglová, J Starý, P Sedláček… in Bone Marrow Transplantation (2000)

Article

Significantly lower relapse rate for TEL/AML1-positive ALL

J Zuna, O Hrušak, M Kalinová, K Mužíková, J Starý, J Trka in Leukemia (1999)

Article

Use of a skin explant model for predicting GVHD in HLA-matched bone marrow transplants – effect of GVHD prophylaxis

Over the last decade we have successfully evaluated the use of a human skin explant assay for predicting acute GVHD in HLA-matched sibling transplants. In the present study, we modified GVHD prophylaxis on an ...

AM Dickinson, I Hromadníková, L Sviland, GH Jackson… in Bone Marrow Transplantation (1999)

Article

Are we ready to curtail testing TEL/AML1 fusion?

O Hrušák, J Trka, J Zuna, J Bartůňková, J Starý in Leukemia (1999)