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Diamine oxidase activities in the large bowel mucosa of ulcerative colitis patients
The term colitis suggests mucosal inflammation as the key event. However, it may be that the disease starts with mucosal hyperproliferation, and inflammation of the impaired mucosa is a succeeding event. There...
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The histamine-diamine oxidase system and mucosal proliferation under the influence of aminoguanidine and seventy percent resection of the rat small intestine
We have suggested previously that the histamine-diamine oxidase system is involved in cell proliferation. Therefore, the diamine oxidase activity and the histamine content were studied during mucosal prolifera...
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Early alterations of rat intestinal diamine oxidase activity by azoxymethane, an intestinal carcinogen
Some mutagenic hydrazino compounds are also diamine oxidase inhibitors. Therefore, this interrelationship was studied for the intestinal carcinogen azoxymethane.In vitro, azoxymethane was a very weak inhibitor of...
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The intestinal diamine oxidase activity under the influence of adaptive proliferation of the intestinal mucosa — a proliferation terminating principle?
Under clinical conditions, intestinal mucosal hyperproliferation together with a reduced diamine oxidase (DAO) activity was found in inflammatory and neoplastic diseases. Therefore, we studied the influence on...
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Article
Reliability and practicability of the fluorometric-fluoroenzymatic histamine determination in pathogenetic studies on peptic ulcer: Detection limits and problems with specificity
Histamine, among various “biologic-physiologic” abnormalities, is considered as a pathogenetic factor in chronic duodenal ulcer disease. The 10–30 per cent difference between its concentration in gastric and d...
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Article
Elevation of the large bowel histamine concentration by aminoguanidine induced diamine oxidase inhibition
In inflammatory diseases of the large bowel a reduced diamine oxidase activity was found which may be related to a reduced oxidative degradation of histamine. An experimental inhibition of diamine oxidase coul...
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Prof. Dr. Dankwart ACKERMANN —The 20th anniversary of his death
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Diamine oxidase as a marker of intestinal integrity in acute appendicitis
In the operative treatment of appendicitis the so called negative appendectomy is an important issue because of its increased morbidity. From the hypothesis that the intestinal diamine oxidase activity is a su...
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Article
Histamine reduces the deamination of putrescinein vitro—but alsoin vivo?
The diamine oxidase catalysed deamination of putrescine was reducedin vitro by histamine at concentrations occurring in the gut. An oral application of histamine, however, had no effect on the enzymic activity. W...
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Article
N-methyl-N-formylhydrazine: A toxic and mutagenic inhibitor of the intestinal diamine oxidase
N-methyl-N-formylhydrazine is the first active intermediate of the poison gyromitrin of the mushroom: false morel. This compound is a non-competitive inhibitor of human intestinal diamine oxidase (ID50=1.6×10−5 ...
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Article
Intestinal monoamine oxidase: Does it have a role in histamine catabolism?
The importance of intestinal diamine oxidase in histamine catabolism was proved in several series of experiments. However, intestinal monoamine oxidase might also be involved in histamine degradation either by...
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The start of a programme for measuring diamine oxidase activity in biopsy specimens of human rectal mucosa
In human subjects, apart from in the kidney, diamine oxidase occurs mainly in the gut. Therefore this enzyme can be used as an indicator of intestinal integrity.
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Human intestinal diamine oxidase: Substrate specificity and comparative inhibitor study
For an 80-fold purified preparation of human intestinal diamine oxidase the optimum conditions of incubation, the substrate and the inhibitor specificity were tested. Putrescine was the most favoured substrate...
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The influence of carcinoma growth on diamine oxidase activity in human gastrointestinal tract
The distribution of diamine oxidase (DAO) activity was studied in patients having no carcinoma disease. Besides in gut DAO occurred in high activity only in kidney and mesenteric lymph nodes.
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Comparison of alterations in the histamine-diamine oxidase system during acute intestinal ischaemia in pigs, dogs and rabbits: Evidence for a uniform pathophysiological mechanism?
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Diamine oxidase activity in gastric and duodenal mucosa of man and other mammals with special reference to the pyloric junction
In the gastric mucosa of human subjects and of various mammals methylation was accepted as the main pathway of histamine catabolism. However, augmentation of gastric acid secretion by aminoguanidine, the stron...
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Diamine oxidase activity and histamine release in dogs following acute mesenteric artery occlusion
Following superior mesenteric artery occlusion and revasclarization in dogs all animals died in a circulatory collapse state. However, pretreatment by aminoguanidine, the strong and specific inhibitor of diami...
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Article
Determination of histaminase (diamine oxidase) activity byo-dianisidine test: Interference of ceruloplasmin
Until nowo-dianisidine was used as an indicator substance in a test system for the determination of diamine oxidase. More recently, however, this substance was also used to measure ceruloplasmin activity. A study...
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Article
Diamine oxidases in the small intestine of rabbits, dogs and pigs: Separation from soluble monoamine oxidases and substrate specificity of the enzymes
The high potency of the small intestine to inactivate vasoactive biogenic amines is a combined effect of diamine and monoamine oxidase activity. Histamine, however, is specifically deaminated by diamine oxidase.
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Article
Evaluation of histamine elimination curves in plasma and whole blood of several circulatory regions: A method for studying kinetics of histamine release in the whole animal
Histamine concentrations in canine whole blood and plasma were determined under several pharmacological, pathophysiological, and clinical conditions, using fluorometric methods.