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    Article

    CTCF mediates dosage- and sequence-context-dependent transcriptional insulation by forming local chromatin domains

    Insulators play a critical role in spatiotemporal gene regulation in animals. The evolutionarily conserved CCCTC-binding factor (CTCF) is required for insulator function in mammals, but not all of its binding ...

    Hui Huang, Quan Zhu, Adam Jussila, Yuanyuan Han, Bogdan Bintu… in Nature Genetics (2021)

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    Article

    Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity

    Defects in pathways governing genomic fidelity have been linked to improved response to immune checkpoint blockade therapy (ICB). Pathogenic POLE/POLD1 mutations can cause hypermutation, yet how diverse mutations...

    **aoxiao Ma, Nadeem Riaz, Robert M. Samstein, Mark Lee, Vladimir Makarov… in Nature Genetics (2022)