76 Result(s)

Article

SETD8 inhibits apoptosis and ferroptosis of Ewing’s sarcoma through YBX1/RAC3 axis

Ewing’s sarcoma (ES) represents a rare yet exceedingly aggressive neoplasm that poses a significant health risk to the pediatric and adolescent population. The clinical outcomes for individuals with relapsed o...

Huimou Chen, **g Hu, **lin **ong, Hongling Chen, Qiaofang Liao… in Cell Death & Disease (2024)

Article

Evaluation of the clinical application value of cytokine expression profiles in the differential diagnosis of prostate cancer

The significance of tumor-secreted cytokines in tumor development has gained substantial attention. Nevertheless, the precise role of tumor-related inflammatory cytokines in prostate cancer (PCa) remains ambig...

Rongfa Chen, Linna Liu, Hui Chen, Chao **ng… in Cancer Immunology, Immunotherapy (2024)

Article

Endothelial DR6 in blood-brain barrier malfunction in Alzheimer’s disease

The impairment of the blood-brain barrier (BBB) has been increasingly recognised as a critical element in the early pathogenesis of Alzheimer’s disease (AD), prompting a focus on brain endothelial cells (BECs)...

**aomin Huang, Junhua Qi, Yixun Su, Ying Zhou, Qi Wang, Taida Huang… in Cell Death & Disease (2024)

Article

Inhibition of acyl-CoA binding protein (ACBP) by means of a GABA_ARγ2-derived peptide

Acyl-CoA binding protein (ACBP) encoded by diazepam binding inhibitor (DBI) is an extracellular inhibitor of autophagy acting on the gamma-aminobutyric acid A receptor (GABA_AR) γ2 subunit (GABA_ARγ2). Here, we sho...

Gerasimos Anagnostopoulos, Ester Saavedra, Flavia Lambertucci… in Cell Death & Disease (2024)

Article

TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2

Abnormal lipid metabolism and lipid accumulation are characteristic hallmarks of renal cell carcinoma (RCC). While there is prior evidence closely linking such lipid accumulation within RCC cells and consequen...

Jun Li, Qian Zhang, Yupeng Guan, Dingzhun Liao, Huikun Chen… in Cell Death & Disease (2024)

Article

AURKA inhibition induces Ewing’s sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis

Ewing’s sarcoma (ES) is a rare and highly aggressive malignant tumor arising from bone and soft tissue. Suffering from intractable or recurrent diseases, the patients’ therapy options are very limited. It is e...

Huimou Chen, **g Hu, **lin **ong, Hongling Chen, Biaojun Lin… in Cell Death & Disease (2024)

Article

BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury

BRISC (BRCC3 isopeptidase complex) is a deubiquitinating enzyme that has been linked with inflammatory processes, but its role in liver diseases and the underlying mechanism are unknown. Here, we investigated ...

Wen Zhang, Kai Liu, Guang-Ming Ren, Yu Wang, Ting Wang, **an Liu… in Cell Death & Disease (2023)

Article

Publisher Correction: Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer

**nyuan Wang, Yujie Zhou, Lijun Ning, **nan Chen, Huimin Chen… in Cell Death & Disease (2023)

Article

Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer

Annexin A10 (ANXA10) belongs to a family of membrane-bound calcium-dependent phospholipid-binding proteins, but its precise function remains unclear. Further research is required to understand its role in sess...

**nyuan Wang, Yujie Zhou, Lijun Ning, **nan Chen, Huimin Chen… in Cell Death & Disease (2023)

Article

Age- and sex-related differences of periodontal bone resorption, cognitive function, and immune state in APP/PS1 murine model of Alzheimer’s disease

The existence of an interconnected mechanism between cognitive disorders and periodontitis has been confirmed by mounting evidence. However, the role of age or sex differences in this mechanism has been less s...

Huiwen Chen, Yue Liao, Xu Zhang, Hui Shen, Dihua Shang… in Journal of Neuroinflammation (2023)

Article

Enhancer of zeste homolog 2 promotes renal fibrosis after acute kidney injury by inducing epithelial-mesenchymal transition and activation of M2 macrophage polarization

Long-term follow-up data indicates that 1/4 patients with acute kidney injury (AKI) will develop to chronic kidney disease (CKD). Our previous studies have demonstrated that enhancer of zeste homolog 2 (EZH2) ...

Xun Zhou, Hui Chen, Yan Hu, **aoyan Ma, **qing Li, Yingfeng Shi… in Cell Death & Disease (2023)

Article

Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants

The omicron variants of SARS-CoV-2 have substantial ability to escape infection- and vaccine-elicited antibody immunity. Here, we investigated the extent of such escape in nine convalescent patients infected w...

Bin Ju, Qi Zhang, Ziyi Wang, Zhen Qin Aw, Peng Chen, Bing Zhou… in Nature Immunology (2023)

Article

Long noncoding RNA ENST00000436340 promotes podocyte injury in diabetic kidney disease by facilitating the association of PTBP1 with RAB3B

Dysfunction of podocytes has been regarded as an important early pathologic characteristic of diabetic kidney disease (DKD), but the regulatory role of long noncoding RNAs (lncRNAs) in this process remains lar...

**xiu Hu, Qimeng Wang, **aoting Fan, Junhui Zhen, Cheng Wang… in Cell Death & Disease (2023)

Article

TRAF6 regulates the abundance of RIPK1 and inhibits the RIPK1/RIPK3/MLKL necroptosis signaling pathway and affects the progression of colorectal cancer

Colorectal cancer cannot be completely cured at present, and it is still an important clinical medical problem. TRAF6 is highly expressed in many malignant tumors. However, the role of TRAF6 in colorectal canc...

Penghang Lin, Chunlin Lin, Ruofan He, Hui Chen, Zuhong Teng… in Cell Death & Disease (2023)

Article

The exhaustion of lymphocytes is the main factor that decreases the sensitivity of QFT-GIT detection in silicosis

Tuberculosis infection is a major complication of silicosis, but there is no study on whether silicosis can affect the sensitivity of QuantiFERON-TB Gold In-Tube (QFT-GIT) assays. This study will analyze the r...

**n Yu, Li-Na Huang, Jun-Chi Xu, Yi-Yan Song, Hui Chen, Cui-Lin Shi… in BMC Immunology (2022)

Article

PRMT3 drives glioblastoma progression by enhancing HIF1A and glycolytic metabolism

Glioblastoma (GBM) is the most common and aggressive primary brain tumor, but the mechanisms underlying tumor growth and progression remain unclear. The protein arginine methyltransferases (PRMTs) regulate a v...

Yunfei Liao, Zaili Luo, Yifeng Lin, Huiyao Chen, Tong Chen… in Cell Death & Disease (2022)

Article

LncRNA ANRIL mediates endothelial dysfunction through BDNF downregulation in chronic kidney disease

Endothelial dysfunction is common in patients with chronic kidney disease (CKD), but the mechanism is unknown. In this study, we found that the circulating ANRIL level was increased and correlated with vascula...

Hong Su, Bing Liu, Huimin Chen, Tingwei Zhang, Tongtong Huang… in Cell Death & Disease (2022)

Article

IDO1 plays a tumor-promoting role via MDM2-mediated suppression of the p53 pathway in diffuse large B-cell lymphoma

With the intensive therapeutic strategies, diffuse large B-cell lymphoma (DLBCL) is still a fatal disease due to its progressive characteristics. Indoleamine 2,3-dioxygenase 1 (IDO1) is a key regulator that ca...

Chengtao Sun, Mengzhen Li, Lian Zhang, Feifei Sun, Huimou Chen… in Cell Death & Disease (2022)

Article

Correction: An obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABA receptor

Gerasimos Anagnostopoulos, Omar Motiño, Si**g Li… in Cell Death & Disease (2022)

Article

The miR-532-E2F1 feedback loop contributes to gastric cancer progression

Gastric cancer (GC) ranks fourth in incidence and mortality worldwide, ascertaining the pathogenesis of GC is crucial for its treatment. E2F1, which regulates the transcription of genes encoding proteins invol...

Shanting Gao, **aomin Bu, Yongyue Gao, Zengtao Bao, Wenchao Shi… in Cell Death & Disease (2022)