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  1. Article

    Evaluation of in vitro and in vivo activity of a multityrosine kinase inhibitor, AL3810, against human thyroid cancer

    Thyroid cancer is the most common type of endocrine neoplasia. Despite recent breakthroughs in treatment of the disease, the treatment of advanced, progressive thyroid cancers remains challenging with limited ...

    Qin **e, Hui Chen, **g Ai, Ying-lei Gao, Mei-yu Geng… in Acta Pharmacologica Sinica (2017)

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  2. Article

    Comparison of the effects of antiarrhythmic drugs flecainide and verapamil on fKv1.4ΔN channel currents in Xenopus oocytes

    To study the effects of Na+ channel blocker flecainide and L-type Ca2+ channel antagonist verapamil on the voltage-gated fKv1.4ΔN channel, an N-terminal-deleted mutant of the ferret Kv1.4 K+ channel.

    Hui Chen, Dong Zhang, Sheng-** Chao, Jiang-hua Ren, Lin Xu… in Acta Pharmacologica Sinica (2013)

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  3. Article

    Plasma ghrelin levels are closely associated with severity and morphology of angiographically-detected coronary atherosclerosis in Chineses patients with diabetes mellitus

    Low plasma ghrelin level was found to be associated with diabetes, and ghrelin was shown to inhibit pro-atherogenic changes in experimental models of atherosclerosis. The aim of this study was to investigate t...

    Min Zhang, Wei-yi Fang, Fang Yuan, **n-kai Qu, Hua Liu… in Acta Pharmacologica Sinica (2012)

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  4. Article

    Oxidized low-density lipoprotein and β-glycerophosphate synergistically induce endothelial progenitor cell ossification

    To investigate the ability of ox-LDL to induce ossification of endothelial progenitor cells (EPCs) in vitro and explored whether oxidative stress, especially hypoxia inducible factor-1α (HIF-1α) and reactive oxyg...

    Li Liu, Zhi-zhong Liu, Hui Chen, Guo-jun Zhang, Yu-hua Kong… in Acta Pharmacologica Sinica (2011)

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  5. Article

    Effects of diltiazem and propafenone on the inactivation and recovery kinetics of fKv1.4 channel currents expressed in Xenopus oocytes

    To investigate the effects of diltiazem, an L-type calcium channel blocker, and propafenone, a sodium channel blocker, on the inactivation and recovery kinetics of fKv1.4, a potassium channel that generates th...

    Dong Zhang, Shi-min Wang, Hui Chen, Xue-jun Jiang… in Acta Pharmacologica Sinica (2011)

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  6. Article

    Cytotoxicity and reversal of multidrug resistance by tryptanthrin-derived indoloquinazolines

    To evaluate the effects and elucidate the mechanisms of a series of indoloquinazolines as novel anticancer agents.

    Sung-tsai Yu, Ji-wang Chern, Tzer-ming Chen, Yi-fan Chiu… in Acta Pharmacologica Sinica (2010)

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