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Article
Open AccessLineage tracing of mutant granulosa cells reveals in vivo protective mechanisms that prevent granulosa cell tumorigenesis
Ovarian granulosa cell tumors (GCTs) originate from granulosa cells (GCs) and represent the most common sex cord-stromal tumor in humans. However, the developmental regulations and molecular mechanisms underly...
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Article
Open AccessThe efficacy and safety of temperature controlled dual-mode radiofrequency in women with vaginal laxity
Vaginal laxity could negatively influence women’s sexual function. This study aimed to explore the efficacy and safety of temperature controlled dual-mode (monopolar and bipolar) radiofrequency (RF) in women w...
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Article
Open AccessHDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge
It is known that granulosa cells (GCs) mediate gonadotropin-induced oocyte meiosis resumption by releasing EGF-like factors in mammals, however, the detailed molecular mechanisms remain unclear. Here, we demon...
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Article
Open AccessNatriuretic peptides improve the developmental competence of in vitro cultured porcine oocytes
Natriuretic peptides (NPs), brain and C type NPs (BNP and CNP), were involved in the maintenance of porcine oocyte meiotic arrest. The present study investigated the effects of NPs on developmental competence ...
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Article
Open AccessEstrogen receptors in granulosa cells govern meiotic resumption of pre-ovulatory oocytes in mammals
In mammals, oocytes are arrested at the diplotene stage of meiosis I until the pre-ovulatory luteinizing hormone (LH) surge triggers meiotic resumption through the signals in follicular granulosa cells. In thi...