446 Result(s)
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Article
Hong-** Liang
Life Sciences
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Article
Open AccessEffects of different energy levels in low-protein diet on liver lipid metabolism in the late-phase laying hens through the gut-liver axis
The energy/protein imbalance in a low-protein diet induces lipid metabolism disorders in late-phase laying hens. Reducing energy levels in the low-protein diet to adjust the energy-to-protein ratio may improve...
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Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption
The low-carbohydrate ketogenic diet (KD) has long been practiced for weight loss, but the underlying mechanisms remain elusive. Gut microbiota and metabolites have been suggested to mediate the metabolic chang...
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TBC1D1 is an energy-responsive polarization regulator of macrophages via governing ROS production in obesity
Energy status is linked to the production of reactive oxygen species (ROS) in macrophages, which is elevated in obesity. However, it is unclear how ROS production is upregulated in macrophages in response to e...
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Improved seed yield and phosphorus accumulation in soybean are associated with the enhanced root exudates in south-west China
Shoot traits related to soybean yield improvement are well characterized, but little is known about changes in root traits and their contribution to yield improvements under different P levels.
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Spatial and widely targeted metabolomics and anatomical analysis reveal the mechanisms associated with petal bicolor patterning of two Dendrobium species
Orchid flowers possess high ornamental value owing to their delicate structure and color. The color patterns are a result of unbalanced pigment distribution among the petal segments, with bicolor being the mos...
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Trans-nuclease activity of Cas9 activated by DNA or RNA target binding
Type V and type VI CRISPR–Cas systems have been shown to cleave nonspecific single-stranded DNA (ssDNA) or single-stranded RNA (ssRNA) in trans, but this has not been observed in type II CRISPR–Cas systems using ...
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Global convergence in terrestrial gross primary production response to atmospheric vapor pressure deficit
Atmospheric vapor pressure deficit (VPD) increases with climate warming and may limit plant growth. However, gross primary production (GPP) responses to VPD remain a mystery, offering a significant source of u...
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Metagenomic analysis of individual mosquito viromes reveals the geographical patterns and drivers of viral diversity
Mosquito transmitted viruses are responsible for an increasing burden of human disease. Despite this, little is known about the diversity and ecology of viruses within individual mosquito hosts. Here, using a ...
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Open AccessImpact of LDLR polymorphisms on lipid levels and atorvastatin’s efficacy in a northern Chinese adult Han cohort with dyslipidemia
Dyslipidemia, a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), is influenced by genetic variations, particularly those in the low-density lipoprotein receptor (LDLR) gene. This stu...
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Open AccessCombination of bone marrow mesenchymal stem cells and moxibustion restores cyclophosphamide-induced premature ovarian insufficiency by improving mitochondrial function and regulating mitophagy
Premature ovarian insufficiency (POI) is a major cause of infertility. In this study, we aimed to investigate the effects of the combination of bone marrow mesenchymal stem cells (BMSCs) and moxibustion (BMSCs...
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Open AccessIdentification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure
VPS37A, an ESCRT-I complex component, is required for recruiting a subset of ESCRT proteins to the phagophore for autophagosome closure. However, the mechanism by which VPS37A is targeted to the phagophore rem...
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Open AccessMulti-modal molecular determinants of clinically relevant osteoporosis subtypes
Due to a rapidly aging global population, osteoporosis and the associated risk of bone fractures have become a wide-spread public health problem. However, osteoporosis is very heterogeneous, and the existing s...
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Open AccessMOCAT: multi-omics integration with auxiliary classifiers enhanced autoencoder
Integrating multi-omics data is emerging as a critical approach in enhancing our understanding of complex diseases. Innovative computational methods capable of managing high-dimensional and heterogeneous datas...
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Open AccessFaecal hsa-miR-7704 inhibits the growth and adhesion of Bifidobacterium longum by suppressing ProB and aggravates hepatic encephalopathy
Both gut microbiome and microRNAs (miRNAs) play a role in the development of hepatic encephalopathy (HE). However, the functional link between the microbiome and host-derived miRNAs in faeces remains poorly un...
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Open Accessm6A-methylated KCTD21-AS1 regulates macrophage phagocytosis through CD47 and cell autophagy through TIPR
Blocking immune checkpoint CD47/SIRPα is a useful strategy to engineer macrophages for cancer immunotherapy. However, the roles of CD47-related noncoding RNA in regulating macrophage phagocytosis for lung canc...
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Open AccessGiant pandas in captivity undergo short-term adaptation in nerve-related pathways
Behaviors in captive animals, including changes in appetite, activity level, and social interaction, are often seen as adaptive responses. However, these behaviors may become progressively maladaptive, leading...
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Open AccessCIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer
Tumor cells are usually considered defective in mitochondrial respiration, but human non-small cell lung cancer (NSCLC) tumor tissues are shown to have enhanced glucose oxidation relative to adjacent benign lu...
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Genetic diversity and population structure of the near threatened fish Harpadon nehereus in the Northwest Pacific: implications for conservation
Genetic diversity studies not only improve the understanding of the wild genetic resources of species but also provide a theoretical basis for the protection, development, and utilization of species and formul...
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Open AccessTNFα modulates PANX1 activation to promote ATP release and enhance P2RX7-mediated antitumor immune responses after chemotherapy in colorectal cancer
ATP and its receptor P2RX7 exert a pivotal effect on antitumor immunity during chemotherapy-induced immunogenic cell death (ICD). Here, we demonstrated that TNFα-mediated PANX1 cleavage was essential for ATP r...
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Open AccessCharacterizing immune variation and diagnostic indicators of preeclampsia by single-cell RNA sequencing and machine learning
Preeclampsia is a multifactorial and heterogeneous complication of pregnancy. Here, we utilize single-cell RNA sequencing to dissect the involvement of circulating immune cells in preeclampsia. Our findings re...
