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Open Access25-hydroxycholesterol promotes proliferation and metastasis of lung adenocarcinoma cells by regulating ERβ/TNFRSF17 axis
Lung adenocarcinoma is the main type of lung cancer in women. Our previous findings have evidenced that 25-hydroxycholesterol (25-HC) promotes migration and invasion of lung adenocarcinoma cells (LAC), during ...
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Article
Open AccessEffects of bone marrow sparing radiotherapy on acute hematologic toxicity for patients with locoregionally advanced cervical cancer: a prospective phase II randomized controlled study
To evaluate effects of bone marrow sparing (BMS) radiotherapy on decreasing the incidence of acute hematologic toxicity (HT) for locoregionally advanced cervical cancer (LACC) patients treated by pelvic irradi...
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Article
Open AccessProtective effect of synbiotic combination of Lactobacillus plantarum SC-5 and olive oil extract tyrosol in a murine model of ulcerative colitis
Ulcerative colitisis (UC) classified as a form of inflammatory bowel diseases (IBD) characterized by chronic, nonspecific, and recurrent symptoms with a poor prognosis. Common clinical manifestations of UC inc...
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Article
Open AccessIdentifying functional subtypes of IgA nephropathy based on three machine learning algorithms and WGCNA
IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis, which is a significant cause of renal failure. At present, the classification of IgAN is often limited to pathology, and its molecul...
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Article
Open AccessMulti-omics sequencing revealed endostar combined with cisplatin treated non small cell lung cancer via anti-angiogenesis
Endostar, an anti-angiogenic drug, has been approved for treating non-small cell lung cancer (NSCLC). At present, endostar combined with radiotherapy or chemotherapy has achieved ideal results in the treatment...
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Article
New Three-Dimensional Supramolecular Framework: Crystal Structure and Photocatalytic Property
In this work, benzimidazole (Hbim) and Cu(II) ions ligands were chosen as building blocks to produce a novel Cu(II) compound (CP) based on {Cu4O}cluster, namely, [Cu4OCl6(Hbim)4]n·n(H2O)·2n(EtOH) (1). The investi...
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Article
Open AccessIdentification and validation of eight lysosomes-related genes signatures and correlation with immune cell infiltration in lung adenocarcinoma
Lung cancer is the leading cause of cancer-related death. Lysosomes are key degradative compartments that maintain protein homeostasis. In current study, we aimed to construct a lysosomes-related genes signatu...
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Article
A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency
AIFM1 is a mitochondrial flavoprotein involved in caspase-independent cell death and regulation of respiratory chain complex biogenesis. Mutations in the AIFM1 gene have been associated with multiple clinical phe...
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Article
Synthesis and Fluorescent Characteristics Study of Two Novel Co(II) Complexes
In this work, two novel mixed-ligand CPs that has a compositions of [Co2(µ-Hdppa)2(phen)2(H2O)2] (1) and {[Co(µ-Hdppa)(µ-4,4′-bipy)(H2O)]·H2O}n (2) is achieved through reaction of cobalt salts with the 5-(3,4-Dic...
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Article
Potential Application Values of Two Multicoloured Coordination Compounds as Multicolor Luminescent Materials
Two Co(II)-based coordination compounds, namely {[Co(apc)2]·H2O}n (1) and [Co(apc)2(H2O)2] (2), have been successfully prepared via reaction of a multifunctional ligand 2-aminopyrimidine-5-carboxylic acid (Hapc) ...
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Article
Domain adaptive Sim-to-Real segmentation of oropharyngeal organs
Video-assisted transoral tracheal intubation (TI) necessitates using an endoscope that helps the physician insert a tracheal tube into the glottis instead of the esophagus. The growing trend of robotic-assiste...
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Article
Transformer-based 3D U-Net for pulmonary vessel segmentation and artery-vein separation from CT images
Transformer-based methods have led to the revolutionizing of multiple computer vision tasks. Inspired by this, we propose a transformer-based network with a channel-enhanced attention module to explore context...
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Article
Open AccessFunction and autophagy of monocyte-derived dendritic cells is affected by hepatitis B virus infection
The role of dendritic cells and the autophagy state of dendritic cells in the immune response of hepatitis B virus (HBV) infection was still controversial. In this study, we carefully examined the phenotype, f...
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Application Values of Two Cu(II) Schiff Base Coordination Complexes on Blue Fluorescent Materials
Two Schiff base binuclear Cu(II) compounds, [Cu2(L)2·(H2O)2]·2DMF (1) together with its coordination polymer (CP) [Cu2(L)2·(4,4′-bpy)2]n (2) (H2L is 4-hydroxy-3-((2-hydroxy-5-mercaptobenzylidene)amino)-2H-chromen...
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Article
Open AccessCorrection: M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way
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Open AccessEnhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7
Tyrosine kinase inhibitors (TKIs) that specifically target mutational points in the EGFR gene have significantly reduced suffering and provided greater relief to patients with lung adenocarcinoma (LUAD). The t...
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Article
Flexible Needle Steering with Tethered and Untethered Actuation: Current States, Targeting Errors, Challenges and Opportunities
Accurate needle targeting is critical for many clinical procedures, such as transcutaneous biopsy or radiofrequency ablation of tumors. However, targeting errors may arise, limiting the widespread adoption of ...
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Article
The safety and immunogenicity of inactivated COVID-19 vaccine in old pulmonary tuberculosis patients
The immunogenicity and safety of vaccines against coronavirus disease 2019 (COVID-19) remain unknown in patients with a history of pulmonary tuberculosis (OPTB). Therefore, the safety and effectiveness of inac...
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Open AccessImpaired antibody responses were observed in patients with type 2 diabetes mellitus after receiving the inactivated COVID-19 vaccines
Patients with type 2 diabetes mellitus (T2DM) have been reported to be more susceptible to 2019 novel coronavirus (2019-nCoV) and more likely to develop severe pneumonia. However, the safety and immunological ...
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Article
Open AccessMutation in XPO5 causes adult-onset autosomal dominant familial focal segmental glomerulosclerosis
Focal and segmental glomerulosclerosis (FSGS) is a histological pathology that characterizes a wide spectrum of diseases. Many genes associated with FSGS have been studied previously, but there are still some ...