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Soluble interleukin-2 receptor as a predictive biomarker for poor efficacy of combination treatment with anti-PD-1/PD-L1 antibodies and chemotherapy in non-small cell lung cancer patients

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  1. Article

    Open Access

    Second-line immunosuppressant administration for steroid-refractory immune-related adverse events in patients with lung cancer

    Evidence for use of second-line immunosuppressants for immune-related adverse events (irAEs) is inadequate. Therefore, a multicenter analysis should assess the efficacy of second-line immunosuppressants for se...

    Shinsuke Ogusu, Yuhei Harutani, Takehiro Tozuka in Cancer Immunology, Immunotherapy (2023)

  2. Article

    Open Access

    Dissociated responses at initial computed tomography evaluation is a good prognostic factor in non-small cell lung cancer patients treated with anti-programmed cell death-1/ligand 1 inhibitors

    Dissociated responses (DR) are phenomena in which some tumors shrink, whereas others progress during treatment of patients with cancer. The purpose of the present study was to evaluate the frequency and progno...

    Takehiro Tozuka, Satoru Kitazono, Hiroaki Sakamoto, Hiroshi Yoshida in BMC Cancer (2020)

  3. Article

    Open Access

    Real-world study of afatinib in first-line or re-challenge settings for patients with EGFR mutant non-small cell lung cancer

    Afatinib, a second-generation epidermal growth factor receptor (EGFR)—tyrosine kinase inhibitor (TKI) for mutant non-small cell lung cancer (NSCLC), was approved in Japan in 2014. This study evaluated clinical...

    Hisashi Tanaka, Kageaki Taima, Masamichi Itoga, Yoshiko Ishioka in Medical Oncology (2019)