37 Result(s)
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Article
Helen Jones
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Article
Open AccessA multi-method exploration of a cardiac rehabilitation service delivered by registered Clinical Exercise Physiologists in the UK: key learnings for current and new services
Cardiac rehabilitation has been identified as having the most homogenous clinical exercise service structure in the United Kingdom (UK), but inconsistencies are evident in staff roles and qualifications within...
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Open AccessRelation Between Endothelial Dysfunction and Exercise Training-Mediated Adaptation in Cardiovascular Risk Factors, Cardiorespiratory Fitness, and Vascular Health in Humans: A secondary analysis
A priori cardiovascular (CV) health status may impact reductions in risk factors and CV mortality and morbidity following exercise training, although this is not fully understood. Therefore, the purpose of the...
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Open AccessExploratory assessment of right ventricular structure and function during prolonged endurance cycling exercise
A reduction in right ventricular (RV) function during recovery from prolonged endurance exercise has been documented alongside RV dilatation. A relative elevation in pulmonary artery pressure and therefore RV ...
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Open AccessSuccessful ABO and HLA incompatible kidney transplantation in children in the UK
There is increasing evidence of good short-term and medium-term outcomes of ABO incompatible (ABOi) and HLA incompatible (HLAi) kidney transplantation with pre-transplant positive crossmatches in paediatric pr...
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Open AccessThe impact of age, sex, cardio-respiratory fitness, and cardiovascular disease risk on dynamic cerebral autoregulation and baroreflex sensitivity
Humans display an age-related decline in cerebral blood flow and increase in blood pressure (BP), but changes in the underlying control mechanisms across the lifespan are less well understood. We aimed to; (1)...
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Open Access‘Fetal side’ of the placenta: anatomical mis-annotation of carbon particle ‘transfer’ across the human placenta
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Open AccessClinical practice guidelines standardisation of immunosuppressive and anti-infective drug regimens in UK paediatric renal transplantation: the harmonisation programme
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Open AccessCocoa-flavanols enhance moderate-intensity pulmonary \(\dot{V}{\text{O}}_{2}\) kinetics but not exercise tolerance in sedentary middle-aged adults
Cocoa flavanols (CF) may exert health benefits through their potent vasodilatory effects, which are perpetuated by elevations in nitric oxide (NO) bioavailability. These vasodilatory effects may contribute to ...
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Open AccessCan exercise training enhance the repeated remote ischaemic preconditioning stimulus on peripheral and cerebrovascular function in high-risk individuals?
Repeated exposure to remote ischaemic preconditioning (rIPC; short bouts of non-lethal ischaemia) enhances peripheral vascular function within 1 week; whereas, longer periods of rIPC (~ 1 year) may improve cer...
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Open AccessThe Effect of Exercise During Pregnancy on Maternal and Offspring Vascular Outcomes: a Pilot Study
The aim of this pilot study is to obtain estimates for the change in maternal cerebrovascular (primary) and offspring vascular structure (secondary) during healthy pregnancy that includes structured exercise. ...
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Open AccessPostexercise hypotension and related hemodynamic responses to cycling under heat stress in untrained men with elevated blood pressure
To investigate the effect of heat stress on postexercise hypotension.
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Open AccessThe impact of acute remote ischaemic preconditioning on cerebrovascular function
Remote ischaemic preconditioning (RIPC) refers to the protection conferred to tissues and organs via brief periods of ischaemia in a remote vascular territory, including the brain. Recent studies in humans rep...
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Open AccessHigh-intensity exercise in the evening does not disrupt sleep in endurance runners
To investigate the effect of early evening exercise training at different intensities on nocturnal sleep and cardiac autonomic activity in endurance-trained runners.
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Open AccessCatch-up growth in children with chronic kidney disease started on enteral feeding after 2 years of age
Enteral feeding by tube in chronic kidney disease (CKD) before 2 years of age improves growth. Whether it is effective after this age is unknown. We assessed whether height and weight SDS changed after tube fe...
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Open AccessHistorical reviews of the assessment of human cardiovascular function: interrogation and understanding of the control of skin blood flow
Several techniques exist for the determination of skin blood flow that have historically been used in the investigation of thermoregulatory control of skin blood flow, and more recently, in clinical assessment...
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Open AccessTelehealth in palliative care is being described but not evaluated: a systematic review
Telehealth is growing and its application in palliative care is seen as a solution to pressures on palliative care services. A 2010 UK review reported growing awareness of telehealth in palliative care but a l...
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Open Access3.3 Age- and Sex-specific Reference Intervals for Brachial Artery Flow-mediated Dilation in Healthy Individuals and the Relation with Cardiovascular Risk Factors
Assessment of endothelial function using brachial artery flow-mediated dilation (FMD) predicts future cardiovascular disease (CVD) risk. However, poor adherence to protocol guidelines and lack of reference val...
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Open AccessThe Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study
The discovery that voltage-gated calcium channel genes such as CACNA1C are part of the aetiology of psychiatric disorders has rekindled interest in the therapeutic potential of L-type calcium channel (LTCC) antag...
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Open AccessCandidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes
Olaparib (Lynparza™) is a PARP inhibitor approved for advanced BRCA-mutated (BRCAm) ovarian cancer. PARP inhibitors may benefit patients whose tumours are dysfunctional in DNA repair mechanisms unrelated to BRCA1...
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Open AccessThe outcomes of Perthes’ disease of the hip: a study protocol for the development of a core outcome set
Perthes’ disease is an idiopathic osteonecrosis of a developmental hip that is most frequent in Northern Europe. Currently, the absence of a common set of standardised outcomes makes comparisons between studie...
