5 Result(s)
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Article
The benzodiazepine inverse agonist RO19-4603 exerts prolonged and selective suppression of ethanol intake in alcohol-preferring (P) rats
The time course of the benzodiazepine (BDZ) inverse agonist RO19-4603 in antagonizing ethanol (EtOH) intake was investigated in alcohol-preferring (P) rats (n=7) maintained on 24-h continuous free-choice access t...
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Article
Ethanol self-administration in freely feeding and drinking rats: effects of Ro15-4513 alone, and in combination with Ro15-1788 (flumazenil)
Recent work in our laboratory demonstrated that Ro15-4513, a partial inverse benzodiazepine (BDZ) agonist, decreases ethanol (ETOH) self-administration in rodents under fluid deprivation conditions. The presen...
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Article
Interactions of Ro15-4513, Ro15-1788 (flumazenil) and ethanol on measures of exploration and locomotion in rats
The present study investigated the role of the GABAA-benzodiazepine (BDZ) receptor complex in mediating ethanol (ETOH)-induced increases in exploration (head-dip**) and locomotion of rats in a holeboard test. M...
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Article
The δ2-opioid receptor antagonist naltriben reduces motivated responding for ethanol
Rationale: Given that alcoholics drink for different reasons, it is not likely that a single pharmacotherapeutic agent will be equally effective for all alcoholics. Hence, the developme...
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Article
A high affinity ligand for GABAA-receptor containing α5 subunit antagonizes ethanol’s neurobehavioral effects in Long-Evans rats
Previously, we reported that the GABAA receptor containing α5 subunit played a significant role in the reinforcing actions of EtOH in rats selectively bred to consume alcohol. However, the role of the α5 receptor...
