612 Result(s)
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Article
Han-** Kim
Biomedicine
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Open AccessMAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis
The asymmetric division of stem cells permits the maintenance of the cell population and differentiation for harmonious progress. Develo** mouse incisors allows inspection of the role of the stem cell niche ...
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Cell membrane camouflaged nanoparticle strategy and its application in brain disease: a review
Drug delivery to the brain is difficult, owing of the presence of a unique structure called the blood–brain barrier (BBB). Thus, strategies that facilitate drug delivery to the brain lesion sites via BBB penet...
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Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague–Dawley rats and Beagle dogs
The emergence of coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a pandemic, prompting rapid vaccine development. Although vaccines are effective, t...
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Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer
Metastasis occurs frequently after resection of pancreatic cancer (PaC). In this study, we hypothesized that multi-parametric analysis of pre-metastatic liver biopsies would classify patients according to thei...
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Open AccessMonitoring measurable residual disease in paediatric acute lymphoblastic leukaemia using immunoglobulin gene clonality based on next-generation sequencing
Assessment of measurable residual disease (MRD) is an essential prognostic tool for B-lymphoblastic leukaemia (B-ALL). In this study, we evaluated the utility of next-generation sequencing (NGS)–based MRD asse...
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Open AccessAntitumor activity of afatinib in EGFR T790M-negative human oral cancer therapeutically targets mTOR/Mcl-1 signaling axis
This study investigates the role and effectiveness of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) in oral cancer, focusing on the clinical relevance of EGFR and myeloid cell leu...
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Open AccessEditorial expression of concern: Protective effect of Curcuma longa L. extract on CCl4-induced acute hepatic stress
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Open AccessBiomaterials-enabled electrical stimulation for tissue healing and regeneration
The electrical microenvironment is considered a pivotal determinant in various pathophysiological processes, including tissue homeostasis and wound healing. Consequently, extensive research endeavors have been...
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Open AccessAntileukemic potential of methylated indolequinone MAC681 through immunogenic necroptosis and PARP1 degradation
Despite advancements in chronic myeloid leukemia (CML) therapy with tyrosine kinase inhibitors (TKIs), resistance and intolerance remain significant challenges. Leukemia stem cells (LSCs) and TKI-resistant cel...
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A review on the nanotechnology-based approaches for managing sexually transmitted infections
Sexually transmitted infections (STIs) are a major public health concern, accounting for millions of new infections each year and a high mortality rate. Acute diseases and infertility are also associated with ...
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Open AccessA multimodal virtual vision platform as a next-generation vision system for a surgical robot
Robot-assisted surgery platforms are utilized globally thanks to their stereoscopic vision systems and enhanced functional assistance. However, the necessity of ergonomic improvement for their use by surgeons ...
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Open AccessRNA expression of 6 genes from metastatic mucosal gastric cancer serves as the global prognostic marker for gastric cancer with functional validation
Molecular analysis of advanced tumors can increase tumor heterogeneity and selection bias. We developed a robust prognostic signature for gastric cancer by comparing RNA expression between very rare early gast...
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Open AccessTLR7-dependent eosinophil degranulation links psoriatic skin inflammation to small intestinal inflammatory changes in mice
Recent evidence of gut microbiota dysbiosis in the context of psoriasis and the increased cooccurrence of inflammatory bowel disease and psoriasis suggest a close relationship between skin and gut immune respo...
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Integrative multi-omics profiling in human decedents receiving pig heart xenografts
In a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human decedents did not show evidence of acute-onset cellular- or antibody-mediated rejection. Here, to better understand th...
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Layered silicate nanoparticles as a non-injectable drug delivery system for biomacromolecules
Safe, efficient, and patient-friendly drug delivery systems are critical for enhancing therapeutic efficacy and the clinical application of drugs. Hence, various organic, inorganic, and hybrid materials have b...
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Open AccessExtracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection
The progressive and irreversible degeneration of retinal ganglion cells (RGCs) and their axons is the major characteristic of glaucoma, a leading cause of irreversible blindness worldwide. Nicotinamide adenine...
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Open AccessWhole-brain dopamine transporter binding pattern predicts survival in multiple system atrophy
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The complement factor H-related protein-5 (CFHR5) exacerbates pathological bone formation in ankylosing spondylitis
Ankylosing spondylitis (AS) is a chronic inflammatory disease, characterized by excessive new bone formation. We previously reported that the complement factor H-related protein-5 (CFHR5), a member of the huma...
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Open AccessOvercoming BRAF and CDK4/6 inhibitor resistance by inhibiting MAP3K3-dependent protection against YAP lysosomal degradation
Transcriptional programs governed by YAP play key roles in conferring resistance to various molecular-targeted anticancer agents. Strategies aimed at inhibiting YAP activity have garnered substantial interest ...
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Open AccessRecent advances in extracellular vesicles for therapeutic cargo delivery
Exosomes, which are nanosized vesicles secreted by cells, are attracting increasing interest in the field of biomedical research due to their unique properties, including biocompatibility, cargo loading capaci...
