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Article
Defining new surrogate markers for CKD progression
At a recent meeting of international experts on clinical aspects of progressive chronic kidney disease (CKD), an extensive analysis of extant clinical trials was used to develop more effective and economical s...
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Article
Remnant nephron physiology and the progression of chronic kidney disease
In chronic kidney disease, ongoing failure of individual nephrons leads to the progressive loss of renal function. This process results in part from a cellular and molecular response to injury that represents ...
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Article
Tubulointerstitial injury and the progression of chronic kidney disease
In chronic kidney disease (CKD), once injury from any number of disease processes reaches a threshold, there follows an apparently irreversible course toward decline in kidney function. The tubulointerstitium ...
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Article
A conceptual framework for the molecular pathogenesis of progressive kidney disease
The data regarding the pathogenesis of progressive kidney disease implicate cytokine effects, physiological factors, and myriad examples of relatively nonspecific cellular dysfunction. The sheer volume of info...
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Article
Cell signal transduction through the mitogen-activated protein kinase pathway
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Article
Integrin receptors, the cytoskeleton, and glomerular cell function
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Article
Balance between matrix synthesis and degradation: a determinant of glomerulosclerosis
In glomerular health and disease, the balance between extracellular matrix (ECM) protein synthesis and degradation determines the amount of matrix that accumulates locally. While cell and whole animal regulati...
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Article
Apoptosis: death as a “vital” biological function
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Article
Immunization practices in childhood nephrotic syndrome: a survey of North American pediatric nephrologists
The indications for immunizing children with minimal change nephrotic syndrome are a subject of some controversy, since it has been reported that immunization may not be effective or may serve as an immunogeni...
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Article
Call for a registry of complications of immunization in nephrotic children!
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Article
The endothelium as an immune organ: studies of endothelial-leukocyte interactions
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Article
Regulation of cell function by extracellular matrix
The extracellular matrix (ECM) provides structural support and adhesive substrates for the body tissues. Recent advances in our understanding of the biology of matrix indicate that the ECM also plays a signifi...
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Article
Hormonal mediators of immune function: new targets for therapeutic intervention
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Article
Steroid-dependent nephrotic syndrome following renal transplantation for congenital nephrotic syndrome
A boy developed recurrent steroid-responsive nephrotic syndrome following renal transplantation for congenital nephrotic syndrome. The first episode was associated with mild tubulointerstitial rejection on kid...
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Immunological mediators and glomerular cell function
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A regulatory system for soluble immune response suppressor production in steroid-responsive nephrotic syndrome
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Immunology
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Immunology
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The immune system in minimal change nephrotic syndrome
Numerous examples of abnormal immune responsiveness have been described in minimal change nephrotic syndrome (MCNS). The association of MCNS with allergy and with certain genetic markers of immune responsivene...
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The nephrotic syndrome (1988)