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  1. No Access

    Article

    Defining new surrogate markers for CKD progression

    At a recent meeting of international experts on clinical aspects of progressive chronic kidney disease (CKD), an extensive analysis of extant clinical trials was used to develop more effective and economical s...

    H. William Schnaper, Susan L. Furth, Lynne P. Yao in Pediatric Nephrology (2015)

  2. Article

    Remnant nephron physiology and the progression of chronic kidney disease

    In chronic kidney disease, ongoing failure of individual nephrons leads to the progressive loss of renal function. This process results in part from a cellular and molecular response to injury that represents ...

    H. William Schnaper in Pediatric Nephrology (2014)

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    Article

    Tubulointerstitial injury and the progression of chronic kidney disease

    In chronic kidney disease (CKD), once injury from any number of disease processes reaches a threshold, there follows an apparently irreversible course toward decline in kidney function. The tubulointerstitium ...

    Kavita S. Hodgkins, H. William Schnaper in Pediatric Nephrology (2012)

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    A conceptual framework for the molecular pathogenesis of progressive kidney disease

    The data regarding the pathogenesis of progressive kidney disease implicate cytokine effects, physiological factors, and myriad examples of relatively nonspecific cellular dysfunction. The sheer volume of info...

    H. William Schnaper, Susan C. Hubchak, Constance E. Runyan… in Pediatric Nephrology (2010)

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    Article

    Cell signal transduction through the mitogen-activated protein kinase pathway

    H. William Schnaper in Pediatric Nephrology (1998)

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    Integrin receptors, the cytoskeleton, and glomerular cell function

    H. William Schnaper in Pediatric Nephrology (1996)

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    Balance between matrix synthesis and degradation: a determinant of glomerulosclerosis

    In glomerular health and disease, the balance between extracellular matrix (ECM) protein synthesis and degradation determines the amount of matrix that accumulates locally. While cell and whole animal regulati...

    H. William Schnaper in Pediatric Nephrology (1995)

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    Article

    Apoptosis: death as a “vital” biological function

    H. William Schnaper in Pediatric Nephrology (1994)

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    Article

    Immunization practices in childhood nephrotic syndrome: a survey of North American pediatric nephrologists

    The indications for immunizing children with minimal change nephrotic syndrome are a subject of some controversy, since it has been reported that immunization may not be effective or may serve as an immunogeni...

    H. William Schnaper in Pediatric Nephrology (1994)

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    Call for a registry of complications of immunization in nephrotic children!

    H. William Schnaper in Pediatric Nephrology (1994)

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    The endothelium as an immune organ: studies of endothelial-leukocyte interactions

    H. William Schnaper in Pediatric Nephrology (1993)

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    Article

    Regulation of cell function by extracellular matrix

    The extracellular matrix (ECM) provides structural support and adhesive substrates for the body tissues. Recent advances in our understanding of the biology of matrix indicate that the ECM also plays a signifi...

    H. William Schnaper, Hynda K. Kleinman in Pediatric Nephrology (1993)

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    Article

    Hormonal mediators of immune function: new targets for therapeutic intervention

    H. William Schnaper in Pediatric Nephrology (1992)

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    Article

    Steroid-dependent nephrotic syndrome following renal transplantation for congenital nephrotic syndrome

    A boy developed recurrent steroid-responsive nephrotic syndrome following renal transplantation for congenital nephrotic syndrome. The first episode was associated with mild tubulointerstitial rejection on kid...

    Pascale H. Lane, H. William Schnaper, Robert L. Vernier… in Pediatric Nephrology (1991)

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    Article

    Immunological mediators and glomerular cell function

    H. William Schnaper in Pediatric Nephrology (1991)

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    A regulatory system for soluble immune response suppressor production in steroid-responsive nephrotic syndrome

    H. William Schnaper in Pediatric Nephrology (1991)

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    Immunology

    H. William Schnaper in Pediatric Nephrology (1990)

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    Immunology

    H. William Schnaper in Pediatric Nephrology (1989)

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    Article

    The immune system in minimal change nephrotic syndrome

    Numerous examples of abnormal immune responsiveness have been described in minimal change nephrotic syndrome (MCNS). The association of MCNS with allergy and with certain genetic markers of immune responsivene...

    H. William Schnaper in Pediatric Nephrology (1989)

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    Article

    The nephrotic syndrome (1988)

    H. William Schnaper in Pediatric Nephrology (1988)

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