101 Result(s)

Article

Direct radical functionalization of native sugars

Naturally occurring (native) sugars and carbohydrates contain numerous hydroxyl groups of similar reactivity^1,2. Chemists, therefore, rely typically on laborious, multi-step protecting-group strategies³ to conver...

Yi Jiang, Yi Wei, Qian-Yi Zhou, Guo-Quan Sun, **a-** Fu, Nikita Levin… in Nature (2024)

Article

Revealing brain cell-stratified causality through dissecting causal variants according to their cell-type-specific effects on gene expression

The human brain has been implicated in the pathogenesis of several complex diseases. Taking advantage of single-cell techniques, genome-wide association studies (GWAS) have taken it a step further and revealed...

Ruo-Han Hao, Tian-Pei Zhang, Feng Jiang, Jun-Hui Liu… in Nature Communications (2024)

Article

Effect of endoscopic therapy and drug therapy on prognosis and rebleeding in patients with esophagogastric variceal bleeding

Esophagogastric variceal bleeding (EVB) is one of the common digestive system emergencies with poor prognosis and high rate of rebleeding after treatment. To explore the effects of endoscopic therapy and drug ...

**g-**g Jiang, Chun Gao, Jun-feng Mao, Guo-yuan Yang, Jun Huang… in Scientific Reports (2024)

Article

Camrelizumab and apatinib plus induction chemotherapy and concurrent chemoradiotherapy in stage N3 nasopharyngeal carcinoma: a phase 2 clinical trial

The antiangiogenic agent apatinib has been shown to clinically improve responses to immune checkpoint inhibitors in several cancer types. Patients with N3 nasopharyngeal carcinoma have a high risk of distant m...

Hu Liang, Yao-Fei Jiang, Guo-Ying Liu, Lin Wang, Jian-Wei Wang… in Nature Communications (2024)

Article

Addendum: Cellular differentiation into hyphae and spores in halophilic archaea

Shu-Kun Tang, **ao-Yang Zhi, Yao Zhang, Kira S. Makarova… in Nature Communications (2024)

Article

Toripalimab plus capecitabine in the treatment of patients with residual nasopharyngeal carcinoma: a single-arm phase 2 trial

Patients with residual nasopharyngeal carcinoma after receiving definitive treatment have poor prognoses. Although immune checkpoint therapies have achieved breakthroughs for treating recurrent and metastatic ...

Xun Cao, Hao-Yang Huang, Chi-**ong Liang, Zhuo-Chen Lin… in Nature Communications (2024)

Article

Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy

Procaspase 9 is the initiator caspase for apoptosis, but how its levels and activities are maintained remains unclear. The gigantic Inhibitor-of-Apoptosis Protein BIRC6/BRUCE/Apollon inhibits both apoptosis an...

Shuo-Shuo Liu, Tian-**a Jiang, Fan Bu, Ji-Lan Zhao, Guang-Fei Wang… in Nature Communications (2024)

Article

Optimal dilation duration of 10 mm diameter balloons after limited endoscopic sphincterotomy for common bile duct stones: a randomized controlled trial

Limited endoscopic sphincterotomy (EST) combined with endoscopic papillary balloon dilation (EPBD) is widely used. However, the optimal duration of small balloon dilation in choledocholithiasis remains controv...

Yuan-Yuan Li, Yin-Shui Miao, Cai-Feng Wang, **g Yan, **ao-Jiang Zhou… in Scientific Reports (2024)

Article

Association between depression and endometriosis using data from NHANES 2005–2006

Studies on the association between depression and self-reported endometriosis are limited, and further studies are required to investigate this association. Data were collected from the National Health and Nut...

Pan-Wei Hu, **ao-Le Zhang, **ao-Tong Yan, Cong Qi, Guo-**g Jiang in Scientific Reports (2023)

Article

Switch of cell migration modes orchestrated by changes of three-dimensional lamellipodium structure and intracellular diffusion

Cell migration plays important roles in many biological processes, but how migrating cells orchestrate intracellular molecules and subcellular structures to regulate their speed and direction is still not clea...

Chao Jiang, Hong-Yu Luo, **npeng Xu, Shuo-**ng Dou, Wei Li… in Nature Communications (2023)

Article

Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice

An important role for liver in the regulation of adipose tissue thermogenesis upon cold exposure has been suggested; however, the underlying mechanisms remain incompletely defined. Here, we identify elevated s...

Fei **ao, Haizhou Jiang, Zi Li, **aoxue Jiang, Shanghai Chen… in Nature Communications (2023)

Article

Realizing high-capacity all-solid-state lithium-sulfur batteries using a low-density inorganic solid-state electrolyte

Lithium-sulfur all-solid-state batteries using inorganic solid-state electrolytes are considered promising electrochemical energy storage technologies. However, develo** positive electrodes with high sulfur ...

Daiwei Wang, Li-Ji Jhang, Rong Kou, Meng Liao, Shiyao Zheng… in Nature Communications (2023)

Article

Cellular differentiation into hyphae and spores in halophilic archaea

Several groups of bacteria have complex life cycles involving cellular differentiation and multicellular structures. For example, actinobacteria of the genus Streptomyces form multicellular vegetative hyphae, aer...

Shu-Kun Tang, **ao-Yang Zhi, Yao Zhang, Kira S. Makarova… in Nature Communications (2023)

Article

Structural insights into the elevator-type transport mechanism of a bacterial ZIP metal transporter

The Zrt-/Irt-like protein (ZIP) family consists of ubiquitously expressed divalent metal transporters critically involved in maintaining systemic and cellular homeostasis of zinc, iron, and manganese. Here, we...

Yao Zhang, Yuhan Jiang, Kaifu Gao, Dexin Sui, Peixuan Yu, Min Su… in Nature Communications (2023)

Article

A pilot study of neoadjuvant combination of anti-PD-1 camrelizumab and VEGFR2 inhibitor apatinib for locally advanced resectable oral squamous cell carcinoma

Novel neoadjuvant therapy regimens are warranted for oral squamous cell carcinoma (OSCC). In this phase I trial (NCT04393506), 20 patients with locally advanced resectable OSCC receive three cycles of camreliz...

Wu-tong Ju, Rong-hui **a, Dong-wang Zhu, Sheng-** Dou… in Nature Communications (2022)

Article

Catalytically efficient Ni-NiO_x-Y₂O₃ interface for medium temperature water-gas shift reaction

The metal-support interfaces between metals and oxide supports have long been studied in catalytic applications, thanks to their significance in structural stability and efficient catalytic activity. The metal...

Kai Xu, Chao Ma, Han Yan, Hao Gu, Wei-Wei Wang, Shan-Qing Li… in Nature Communications (2022)

Article

Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox

Adipocyte differentiation of bone marrow mesenchymal stem/stromal cells (BMSCs) instead of osteoblast formation contributes to age- and menopause-related marrow adiposity and osteoporosis. Vascular calcificati...

Zhen-**ng Wang, Zhong-Wei Luo, Fu-**ng-Zi Li, Jia Cao… in Nature Communications (2022)

Article

Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors

Peptide hormones and neuropeptides are complex signaling molecules that predominately function through G protein-coupled receptors (GPCRs). Two unanswered questions remaining in the field of peptide-GPCR signa...

Jia Duan, Dan-Dan Shen, Tingting Zhao, Shimeng Guo, **nheng He… in Nature Communications (2022)

Article

Ultrafast coherent control of a hole spin qubit in a germanium quantum dot

Operation speed and coherence time are two core measures for the viability of a qubit. Strong spin-orbit interaction (SOI) and relatively weak hyperfine interaction make holes in germanium (Ge) intriguing cand...

Ke Wang, Gang Xu, Fei Gao, He Liu, Rong-Long Ma, **n Zhang… in Nature Communications (2022)

Article

Two-billion-year-old volcanism on the Moon from Chang’e-5 basalts

The Moon has a magmatic and thermal history that is distinct from that of the terrestrial planets¹. Radioisotope dating of lunar samples suggests that most lunar basaltic magmatism ceased by around 2.9–2.8 billio...

Qiu-Li Li, Qin Zhou, Yu Liu, Zhiyong **ao, Yangting Lin, **-Hua Li, Hong-**a Ma… in Nature (2021)