77 Result(s)

Article

TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice

The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor that affects cellular phenotypes by modulating phagocytosis and metabolism, promoting cell survival, and counteracting inflamm...

Yan Cui, Chao Chen, Zhouqi Tang, Wenjia Yuan, Kaiye Yue… in Cell Death & Disease (2024)

Article

Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

The neuropeptide 26RFa, a member of the RF-amide peptide family, activates the pyroglutamylated RF-amide peptide receptor (QRFPR), a class A GPCR. The 26RFa/QRFPR system plays critical roles in energy homeosta...

Sanshan **, Shimeng Guo, Youwei Xu, **n Li, Canrong Wu, **nheng He… in Cell Discovery (2024)

Article

Comprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities

Germline-somatic mutation interactions are universal and associated with tumorigenesis, but their role in breast cancer, especially in non-Caucasians, remains poorly characterized. We performed large-scale pro...

Chao Chen, Cai-** Lin, Yu-Chen Pei, Ding Ma, Li Liao, Si-Yuan Li… in Cell Discovery (2023)

Article

Genetic diversity of field Fusarium asiaticum and Fusarium graminearum isolates increases the risk of fungicide resistance

Fusarium head blight (FHB) caused by Fusarium species, seriously threatens the safety of wheat (Triticum aestivum) production. Resistant cultivars and fungicides are frequently used to control these FHB pathogens...

Ya-Zhou Zhang, Zhuo Li, Jie Man, Dan Xu, Lan Wen, Chen Yang… in Phytopathology Research (2023)

Article

The pseudoenzyme ADPRHL1 affects cardiac function by regulating the ROCK pathway

Pseudoenzymes, catalytically deficient variants of active enzymes, have a wide range of regulatory functions. ADP-ribosylhydrolase-like 1 (ADPRHL1), a pseudoenzyme belonging to a small group of ADP-ribosylhydr...

Lei Tian, Tianwei Guo, Fujian Wu, Rui Bai, Sinan Ai… in Stem Cell Research & Therapy (2023)

Article

Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance

Posttranslational modification dramatically enhances protein complexity, but the function and precise mechanism of novel lysine acylation modifications remain unknown. Chemoresistance remains a daunting challe...

Yan He, Can-Can Zheng, **g Yang, Shu-Jun Li, Tao-Yang Xu, **an Wei… in Cell Discovery (2023)

Article

Widely targeted quantitative lipidomics and prognostic model reveal plasma lipid predictors for nasopharyngeal carcinoma

Dysregulation of lipid metabolism is closely associated with cancer progression. The study aimed to establish a prognostic model to predict distant metastasis-free survival (DMFS) in patients with nasopharynge...

** Chen, Ying-xue Li, Xun Cao, Meng-yun Qiang… in Lipids in Health and Disease (2023)

Article

Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics

Glioma stem cells (GSCs) are responsible for glioma recurrence and drug resistance, yet the mechanisms underlying their maintenance remains unclear. This study aimed to identify enhancer-controlled genes invol...

Yu-meng Sun, Yi-meng Zhang, Hai-liang Shi, Song Yang, Yin-long Zhao… in Hereditas (2023)

Article

Elevated Interleukin-37 Associated with Dengue Viral Load in Patients with Dengue Fever

Dengue remains a public health issue worldwide. Similar to chronic infectious diseases, stimulation of cytokine production is not enough to drive immune effector cells for effective virus clearance. One possib...

Jun-Ai Zhang, Jia-Jun Wang, Wen-Ting Zhang, Li Zhang, Bi-Ying Zheng… in Current Microbiology (2023)

Article

Metavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes

The increasing prevalence and expanding distribution of tick-borne viruses globally have raised health concerns, but the full repertoire of the tick virome has not been assessed. We sequenced the meta-transcri...

Xue-Bing Ni, **ao-Ming Cui, **-Yue Liu, Run-Ze Ye, Yu-Qian Wu… in Nature Microbiology (2023)

Article

Correction: Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Wan-jun Yang, Rong-chang Cao, Wang **ao, **ao-lou Zhang, Hao Xu… in Cell Death & Disease (2022)

Article

Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Noninflammatory clearance of dying cells by professional phagocytes, termed efferocytosis, is fundamental in both homeostasis and inflammatory fibrosis disease but has not been confirmed to occur in chronic pa...

Wan-jun Yang, Rong-chang Cao, Wang **ao, **ao-lou Zhang, Hao Xu… in Cell Death & Disease (2022)

Article

Single-cell reconstruction reveals input patterns and pathways into corticotropin-releasing factor neurons in the central amygdala in mice

Corticotropin-releasing factor (CRF) neurons are one of the most densely distributed cell types in the central amygdala (CeA), and are involved in a wide range of behaviors including anxiety and learning. Howe...

Chuan Huang, Yu Wang, Peng Chen, Qing-Hong Shan, Hao Wang… in Communications Biology (2022)

Article

An NF-κB/OVOL2 circuit regulates glucose import and cell survival in non-small cell lung cancer

Tumor cells tend to utilize glycolysis rather than aerobic respiration even under aerobic conditions. OVOL2, an inhibitory C2H2 zinc finger transcription factor, is a potential tumor suppressor in cancers. How...

Rui Zhang, Guo-Jun Geng, Jian-Guang Guo, Yan-Jun Mi… in Cell Communication and Signaling (2022)

Article

Extracellular vesicles from adipose-derived stem cells promote microglia M2 polarization and neurological recovery in a mouse model of transient middle cerebral artery occlusion

Adipose-derived stem cells (ADSCs) and their extracellular vesicles (EVs) have therapeutic potential in ischemic brain injury, but the underlying mechanism is poorly understood. The current study aimed to expl...

**aowen Hu, Jiaji Pan, Yongfang Li, Yixu Jiang… in Stem Cell Research & Therapy (2022)

Article

Correction to: Ocean acidification alters the thermal performance curves of brooded larvae from the reef coral Pocillopora damicornis

Lei Jiang, You-Fang Sun, Yu-Yang Zhang, Yuan Tian, **n-Ming Lei… in Coral Reefs (2021)

Article

Author Correction: Discovery of new genetic loci for male sexual orientation in Han population

Shao-Hua Hu, Hai-mei Li, Hao Yu, Yan Liu, Chen-**ng Liu, **an-bo Zuo… in Cell Discovery (2021)

Article

Association Map** and Functional Analysis of Rice Cold Tolerance QTLs at the Bud Burst Stage

Cold tolerance at the bud burst stage (CTB) is a key trait for direct-seeded rice. Although quantitative trait loci (QTL) affecting CTB in rice have been mapped using traditional linkage map** and genome-wid...

Dan Wang, Zhuo Liu, Yinghui **ao, **onglun Liu, Yue Chen, Zhuo Zhang, Houxiang Kang… in Rice (2021)

Article

Accumulation of LDL/ox-LDL in the necrotic region participates in osteonecrosis of the femoral head: a pathological and in vitro study

Osteonecrosis of the femoral head (ONFH) is a common but intractable disease that appears to involve lipid metabolic disorders. Although numerous studies have demonstrated that high blood levels of low-density...

**n-Yuan Wang, Tian-Le Ma, Kang-Ning Chen, Zhi-Ying Pang… in Lipids in Health and Disease (2021)

Article

Fungal diversity notes 1387–1511: taxonomic and phylogenetic contributions on genera and species of fungal taxa

This article is the 13th contribution in the Fungal Diversity Notes series, wherein 125 taxa from four phyla, ten classes, 31 orders, 69 families, 92 genera and three genera incertae sedis are treated, demonstrat...

Saranyaphat Boonmee, Dhanushka N. Wanasinghe, Mark S. Calabon… in Fungal Diversity (2021)