53 Result(s)

Article

TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice

The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor that affects cellular phenotypes by modulating phagocytosis and metabolism, promoting cell survival, and counteracting inflamm...

Yan Cui, Chao Chen, Zhouqi Tang, Wenjia Yuan, Kaiye Yue… in Cell Death & Disease (2024)

Article

Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

The neuropeptide 26RFa, a member of the RF-amide peptide family, activates the pyroglutamylated RF-amide peptide receptor (QRFPR), a class A GPCR. The 26RFa/QRFPR system plays critical roles in energy homeosta...

Sanshan **, Shimeng Guo, Youwei Xu, **n Li, Canrong Wu, **nheng He… in Cell Discovery (2024)

Article

Comprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities

Germline-somatic mutation interactions are universal and associated with tumorigenesis, but their role in breast cancer, especially in non-Caucasians, remains poorly characterized. We performed large-scale pro...

Chao Chen, Cai-** Lin, Yu-Chen Pei, Ding Ma, Li Liao, Si-Yuan Li… in Cell Discovery (2023)

Article

The pseudoenzyme ADPRHL1 affects cardiac function by regulating the ROCK pathway

Pseudoenzymes, catalytically deficient variants of active enzymes, have a wide range of regulatory functions. ADP-ribosylhydrolase-like 1 (ADPRHL1), a pseudoenzyme belonging to a small group of ADP-ribosylhydr...

Lei Tian, Tianwei Guo, Fujian Wu, Rui Bai, Sinan Ai… in Stem Cell Research & Therapy (2023)

Article

Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance

Posttranslational modification dramatically enhances protein complexity, but the function and precise mechanism of novel lysine acylation modifications remain unknown. Chemoresistance remains a daunting challe...

Yan He, Can-Can Zheng, **g Yang, Shu-Jun Li, Tao-Yang Xu, **an Wei… in Cell Discovery (2023)

Article

Correction: Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Wan-jun Yang, Rong-chang Cao, Wang **ao, **ao-lou Zhang, Hao Xu… in Cell Death & Disease (2022)

Article

Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Noninflammatory clearance of dying cells by professional phagocytes, termed efferocytosis, is fundamental in both homeostasis and inflammatory fibrosis disease but has not been confirmed to occur in chronic pa...

Wan-jun Yang, Rong-chang Cao, Wang **ao, **ao-lou Zhang, Hao Xu… in Cell Death & Disease (2022)

Article

An NF-κB/OVOL2 circuit regulates glucose import and cell survival in non-small cell lung cancer

Tumor cells tend to utilize glycolysis rather than aerobic respiration even under aerobic conditions. OVOL2, an inhibitory C2H2 zinc finger transcription factor, is a potential tumor suppressor in cancers. How...

Rui Zhang, Guo-Jun Geng, Jian-Guang Guo, Yan-Jun Mi… in Cell Communication and Signaling (2022)

Article

Extracellular vesicles from adipose-derived stem cells promote microglia M2 polarization and neurological recovery in a mouse model of transient middle cerebral artery occlusion

Adipose-derived stem cells (ADSCs) and their extracellular vesicles (EVs) have therapeutic potential in ischemic brain injury, but the underlying mechanism is poorly understood. The current study aimed to expl...

**aowen Hu, Jiaji Pan, Yongfang Li, Yixu Jiang… in Stem Cell Research & Therapy (2022)

Article

Author Correction: Discovery of new genetic loci for male sexual orientation in Han population

Shao-Hua Hu, Hai-mei Li, Hao Yu, Yan Liu, Chen-**ng Liu, **an-bo Zuo… in Cell Discovery (2021)

Article

Discovery of new genetic loci for male sexual orientation in Han population

Epidemiological studies have demonstrated that the genetic factors partly influence the development of same-sex sexual behavior, but most genetic studies have focused on people of primarily European ancestry, ...

Shao-Hua Hu, Hai-mei Li, Hao Yu, Yan Liu, Chen-**ng Liu, **an-bo Zuo… in Cell Discovery (2021)

Article

A negative feedback loop involving NF-κB/TIR8 regulates IL-1β-induced epithelial- myofibroblast transdifferentiation in human tubular cells

Renal tubular epithelial-myofibroblast transdifferentiation (EMT) plays a central role in the development of renal interstitial fibrosis (RIF). The profibrotic cytokine interleukin (IL)-1 and the IL-1 receptor...

Keguo Jiang, Yuying Zhang, Fan He… in Journal of Cell Communication and Signaling (2021)

Article

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca²⁺/CaMKII/Nrf2 signaling pathway

Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven synovitis exacerbates the pathological process. However, precise therapies for M1 macrophage to decrease synovitis ...

Zhongyang Lv, **ngquan Xu, Ziying Sun, Yannick **aofan Yang, Hu Guo… in Cell Death & Disease (2021)

Article

Notch3 inhibits cell proliferation and tumorigenesis and predicts better prognosis in breast cancer through transactivating PTEN

Notch receptors (Notch1–4) play critical roles in tumorigenesis and metastasis of malignant tumors, including breast cancer. Although abnormal Notch activation is related to various tumors, the importance of s...

Yong-Qu Zhang, Yuan-Ke Liang, Yang Wu, Min Chen, Wei-Ling Chen… in Cell Death & Disease (2021)