24 Result(s)

Article

TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice

The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor that affects cellular phenotypes by modulating phagocytosis and metabolism, promoting cell survival, and counteracting inflamm...

Yan Cui, Chao Chen, Zhouqi Tang, Wenjia Yuan, Kaiye Yue… in Cell Death & Disease (2024)

Article

Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

The neuropeptide 26RFa, a member of the RF-amide peptide family, activates the pyroglutamylated RF-amide peptide receptor (QRFPR), a class A GPCR. The 26RFa/QRFPR system plays critical roles in energy homeosta...

Sanshan **, Shimeng Guo, Youwei Xu, **n Li, Canrong Wu, **nheng He… in Cell Discovery (2024)

Article

Comprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities

Germline-somatic mutation interactions are universal and associated with tumorigenesis, but their role in breast cancer, especially in non-Caucasians, remains poorly characterized. We performed large-scale pro...

Chao Chen, Cai-** Lin, Yu-Chen Pei, Ding Ma, Li Liao, Si-Yuan Li… in Cell Discovery (2023)

Article

Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance

Posttranslational modification dramatically enhances protein complexity, but the function and precise mechanism of novel lysine acylation modifications remain unknown. Chemoresistance remains a daunting challe...

Yan He, Can-Can Zheng, **g Yang, Shu-Jun Li, Tao-Yang Xu, **an Wei… in Cell Discovery (2023)

Article

Correction: Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Wan-jun Yang, Rong-chang Cao, Wang **ao, **ao-lou Zhang, Hao Xu… in Cell Death & Disease (2022)

Article

Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Noninflammatory clearance of dying cells by professional phagocytes, termed efferocytosis, is fundamental in both homeostasis and inflammatory fibrosis disease but has not been confirmed to occur in chronic pa...

Wan-jun Yang, Rong-chang Cao, Wang **ao, **ao-lou Zhang, Hao Xu… in Cell Death & Disease (2022)

Article

Author Correction: Discovery of new genetic loci for male sexual orientation in Han population

Shao-Hua Hu, Hai-mei Li, Hao Yu, Yan Liu, Chen-**ng Liu, **an-bo Zuo… in Cell Discovery (2021)

Article

Discovery of new genetic loci for male sexual orientation in Han population

Epidemiological studies have demonstrated that the genetic factors partly influence the development of same-sex sexual behavior, but most genetic studies have focused on people of primarily European ancestry, ...

Shao-Hua Hu, Hai-mei Li, Hao Yu, Yan Liu, Chen-**ng Liu, **an-bo Zuo… in Cell Discovery (2021)

Article

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca²⁺/CaMKII/Nrf2 signaling pathway

Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven synovitis exacerbates the pathological process. However, precise therapies for M1 macrophage to decrease synovitis ...

Zhongyang Lv, **ngquan Xu, Ziying Sun, Yannick **aofan Yang, Hu Guo… in Cell Death & Disease (2021)

Article

Notch3 inhibits cell proliferation and tumorigenesis and predicts better prognosis in breast cancer through transactivating PTEN

Notch receptors (Notch1–4) play critical roles in tumorigenesis and metastasis of malignant tumors, including breast cancer. Although abnormal Notch activation is related to various tumors, the importance of s...

Yong-Qu Zhang, Yuan-Ke Liang, Yang Wu, Min Chen, Wei-Ling Chen… in Cell Death & Disease (2021)

Article

Author Correction: N⁶-methyladenine is incorporated into mammalian genome by DNA polymerase

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

**aoling Liu, Weiyi Lai, Yao Li, Shaokun Chen, Baodong Liu, Ning Zhang… in Cell Research (2021)

Article

New genotypes of Helicobacter Pylori VacA d-region identified from global strains

Pathogenesis of Helicobacter Pylori (HP) vacuolating toxin A (vacA) depends on polymorphic diversity within the signal (s), middle (m), intermediate (i), deletion (d) and c-regions. These regions show distinct al...

Djaleel Muhammad Soyfoo, Yussriya Hanaa Doomah, Dong Xu… in BMC Molecular and Cell Biology (2021)

Article

N⁶-methyladenine is incorporated into mammalian genome by DNA polymerase

**aoling Liu, Weiyi Lai, Yao Li, Shaokun Chen, Baodong Liu, Ning Zhang… in Cell Research (2021)

Article

The YY1/miR-548t-5p/CXCL11 signaling axis regulates cell proliferation and metastasis in human pancreatic cancer

Pancreatic cancer (PC) is a malignant tumor with a poor prognosis and high mortality. However, the biological role of miR-548t-5p in PC has not been reported. In this study, we found that miR-548t-5p expressio...

Wan-Li Ge, Qun Chen, Ling-Dong Meng, Xu-Min Huang, Guo-dong Shi… in Cell Death & Disease (2020)

Article

SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway

Cellular metabolic reprogramming is the main characteristic of cancer cells and identification of targets using this metabolic pattern is extremely important to treat cancers, such as osteosarcoma (OS). In thi...

Shu-Jie Zhao, Yi-Fei Shen, Qing Li, Yun-Jie He, Yun-Kun Zhang… in Cell Death & Disease (2018)

Article

Elimination of stem-like cancer cell side-population by auranofin through modulation of ROS and glycolysis

Cancer side-population (SP) represents a sub-population of stem-like cancer cells that have an important role in drug resistance due to their high expression of the ATP-binding cassette transporter ABCG2 invol...

Guo-**n Hou, Pan-Pan Liu, Shengyi Zhang, Mengqi Yang, Jianwei Liao… in Cell Death & Disease (2018)

Article

H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance

Long noncoding RNA-H19 (H19), an imprinted oncofetal gene, has a central role in carcinogenesis. Hitherto, the mechanism by which H19 regulates cancer stem cells, remains elusive. Here we show that breast cancer ...

Fei Peng, Ting-Ting Li, Kai-Li Wang, Guo-Qing **ao, Ju-Hong Wang… in Cell Death & Disease (2018)

Article

Erratum: A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations

Correction to: Cell Research (2017) 27:386–401. doi:10.1038/cr.2017.17; published online on 27 January 2017 The authors apologized for the mistake of mis-labeling the affiliation for Dr Stuart H Orkin, his aff...

** Han, Hao Yu, Daosheng Huang, Yang Xu, Assieh Saadatpour, **a Li… in Cell Research (2017)

Article

Erratum: A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations

Correction to: Cell Research (2017) 27:386–401. doi:10.1038/cr.2017.17; published online on 27 January 2017 During web production, there is an error in the web site for the labeling of Dr Bin Zhou, his affilia...

** Han, Hao Yu, Daosheng Huang, Yang Xu, Assieh Saadatpour, **a Li… in Cell Research (2017)

Article

A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations

Recent advances have demonstrated the power of small molecules in promoting cellular reprogramming. Yet, the full potential of such chemicals in cell fate manipulation and the underlying mechanisms require fur...

** Han, Hao Yu, Daosheng Huang, Yang Xu, Assieh Saadatpour, **a Li… in Cell Research (2017)