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Article
Open AccessOptimization of building integrated energy scheduling using an improved genetic whale algorithm
Renewable energy generation has become the general trend with increasing environmental problems. However, the instability of renewable energy generation and the diversification of user demand are highlighted a...
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Article
Open AccessPopulation Target-Mediated Pharmacokinetic/Pharmacodynamic Modeling to Evaluate SPI-62 Exposure and Hepatic 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD-1) Inhibition in Healthy Adults
SPI-62 is a small-molecule 11β-hydroxysteroid dehydrogenase type 1 (HSD-1) inhibitor exhibiting complicated nonlinear pharmacokinetics (PK) in human. Previously, we developed a target-mediated drug disposition...
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Article
Open AccessConstant false alarm rate detection of pipeline leakage based on acoustic sensors
During the transportation of oil and gas pipelines, there are many potential factors that can lead to pipeline leakage with serious consequences, making automatic and real-time pipeline leakage detection urgen...
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Article
Open AccessZFP36 loss-mediated BARX1 stabilization promotes malignant phenotypes by transactivating master oncogenes in NSCLC
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with high morbidity and mortality worldwide. Although the dysregulation of BARX1 expression has been shown to be associated with malig...
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Article
Open AccessPalaeobotanical evidence reveals the living conditions of Miocene Lufengpithecus in East Asia
Understanding the relationship between human evolution and environmental changes is the key to lifting the veil on human origin. The hypothesis that environmental changes triggered the divergence of humans fro...
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Article
Open AccessPast rainfall-driven erosion on the Chinese loess plateau inferred from archaeological evidence from Wucheng City, Shanxi
The history of changes in the Earth’s surface can be investigated by numerical modelling of landform evolution. However, such models rely on evidence which is often removed through erosion or other surface pro...
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Article
Erratum to: Enabling electrically tunable radio frequency components with advanced microfabrication and thin film techniques
The original version of this article unfortunately contained a mistake. The mistake is corrected as follows:
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Preface to the special issue on laser processing and micro-nano technology
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Open AccessProteomics-based evaluation of the mechanism underlying vascular injury via DNA interstrand crosslinks, glutathione perturbation, mitogen-activated protein kinase, and Wnt and ErbB signaling pathways induced by crotonaldehyde
Crotonaldehyde (CRA)—one of the major environmental pollutants from tobacco smoke and industrial pollution—is associated with vascular injury (VI). We used proteomics to systematically characterize the present...
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Article
Open AccessA Novel Power Transformer Fault Diagnosis Model Based on Harris-Hawks-Optimization Algorithm Optimized Kernel Extreme Learning Machine
Dissolved gas analysis (DGA) method is widely used to detect the incipient fault of power transformers. This paper presents a novel DGA method for power transformer fault diagnosis based on Harris-Hawks-optimi...
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Article
Open AccessGlyoxal damages human aortic endothelial cells by perturbing the glutathione, mitochondrial membrane potential, and mitogen-activated protein kinase pathways
Exposure to glyoxal, the smallest dialdehyde, is associated with several diseases; humans are routinely exposed to glyoxal because of its ubiquitous presence in foods and the environment. The aim of this study...
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Article
Open AccessInhibiting CBX4 efficiently protects hepatocellular carcinoma cells against sorafenib resistance
This study aimed to investigate the possible role of inhibiting chromobox protein homologue 4 (CBX4) to deregulate of cancer stem cells (CSCs) and to evaluate the contribution of these molecules to sorafenib r...
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Article
Open AccessConstruction of a metastasis-associated ceRNA network reveals a prognostic signature in lung cancer
Lung cancer is the most common cancer worldwide, and metastasis is the leading cause of lung cancer related death. However, the molecular network involved in lung cancer metastasis remains incompletely describ...
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Article
Open AccessA phase 3 study of rituximab biosimilar HLX01 in patients with diffuse large B-cell lymphoma
Rituximab in combination with chemotherapy has shown efficacy in patients with diffuse large B-cell lymphoma (DLBCL) for more than 15 years. HLX01 was developed as the rituximab biosimilar following a stepwise...
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Article
Open AccessCysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones
Many reagents have been developed for cysteine-specific protein modification. However, few of them allow for multi-functionalization of a single Cys residue and disulfide bridging bioconjugation. Herein, we re...
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Article
Open AccessMFAP2 is overexpressed in gastric cancer and promotes motility via the MFAP2/integrin α5β1/FAK/ERK pathway
Gastric cancer (GC) is one of the most common malignancies and its prognosis is extremely poor. This study identifies a novel oncogene, microfibrillar-associated protein 2 (MFAP2) in GC. With integrative reana...
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Article
Open AccessImproving the accuracy and efficacy of diagnosing polycystic ovary syndrome by integrating metabolomics with clinical characteristics: study protocol for a randomized controlled trial
Polycystic ovary syndrome (PCOS) is a complex endocrine syndrome with poorly understood mechanisms. To provide patients with PCOS with individualized therapy, it is critical to precisely diagnose the phenotype...
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Article
Open AccessEctopic expression of BIRC5-targeting miR-101-3p overcomes bone marrow stroma-mediated drug resistance in multiple myeloma cells
Multiple myeloma (MM) cells gain protection against drugs through interaction with bone marrow stromal cells (BMSCs). This form of resistance largely accounts for resistance to therapy in MM patients which war...
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Article
Open AccessPharmacological treatment of inhalation injury after nuclear or radiological incidents: The Chinese and German approach
Inhalation injury is often associated with burns and significantly increases morbidity and mortality. The main toxic components of fire smoke are carbon monoxide, hydrogen cyanide, and irritants. In the case o...
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Article
Open AccessMechanism of hysteresis for composite multi-halide and its superior performance for low grade energy recovery
Sorption hysteresis commonly exists for different sorbents and has a great impact on the performance, and recently it was found that the multi-halide sorbents could reduce the hysteresis phenomena. Here we rep...
