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Article
Unified plastic limit analysis of the cap periphery formation in orbital drilling of titanium alloy
The cap geometry and formation mechanism play a key role in influencing the hole-making quality on the bore exit side and must be the focus of research in orbital drilling of aeronautical metal materials. For ...
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Article
Photocatalytic oxidation of formaldehyde under visible light using BiVO4-TiO2 synthesized via ultrasonic blending
Formaldehyde (HCHO) is one of the primary indoor air pollutants, and efficiently eliminating it, especially at low concentrations, remains challenging. In this study, BiVO4-TiO2 catalyst was developed using ultra...
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Article
P-Wave Doubly Excited States of Positronium Hydride
Three P-wave doubly excited autodissociating resonant states have been unveiled in positronium hydride. The investigation of these states was facilitated through the application of a projection operator method...
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Article
A High-Precision D-Shaped Fiber Polishing Method and its Sensing Characteristics of Different Polishing Depths
In this paper, a simple and low-cost side-wheel polishing machine was designed and fabricated to enable the fabrication of D-shaped optical fibers. Scanning electron microscope (SEM) characterization of the fa...
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Article
Fault diagnosis method for transformer based on NCA and CapSA-RELM
The key to intelligent fault diagnosis for transformer is to find relevant dissolved gas characteristics with the capability of representing different types of faults. However, the existing problem is that usi...
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Article
Open AccessOptimization of building integrated energy scheduling using an improved genetic whale algorithm
Renewable energy generation has become the general trend with increasing environmental problems. However, the instability of renewable energy generation and the diversification of user demand are highlighted a...
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Article
Protection of laryngeal mucosa and function in laryngeal burns by heat absorption of perilaryngeal tissue
The laryngeal tissue carries most of the heat during inhalation injury. This study aims to explore the heat transfer process and the severity of injury inside laryngeal tissue by horizontally studying the temp...
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Article
Open AccessPopulation Target-Mediated Pharmacokinetic/Pharmacodynamic Modeling to Evaluate SPI-62 Exposure and Hepatic 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD-1) Inhibition in Healthy Adults
SPI-62 is a small-molecule 11β-hydroxysteroid dehydrogenase type 1 (HSD-1) inhibitor exhibiting complicated nonlinear pharmacokinetics (PK) in human. Previously, we developed a target-mediated drug disposition...
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Article
Open AccessConstant false alarm rate detection of pipeline leakage based on acoustic sensors
During the transportation of oil and gas pipelines, there are many potential factors that can lead to pipeline leakage with serious consequences, making automatic and real-time pipeline leakage detection urgen...
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Article
Open AccessZFP36 loss-mediated BARX1 stabilization promotes malignant phenotypes by transactivating master oncogenes in NSCLC
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with high morbidity and mortality worldwide. Although the dysregulation of BARX1 expression has been shown to be associated with malig...
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Article
A Pharmacometrics Model to Characterize a New Type of Target-Mediated Drug Disposition (TMDD) – Nonlinear Pharmacokinetics of Small-Molecule PF-07059013 Mediated By Its High-capacity Pharmacological Target Hemoglobin With Positive Cooperative Binding
In general, small-molecule target-mediated drug disposition (TMDD) is caused by the interaction of a drug with its high-affinity, low-capacity pharmacological target. In the current work, we developed a pharma...
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Article
Comparison of heat transfer characteristics between natural ester oil and mineral oil in large oil-immersed transformer
Natural ester insulating oil has the advantages of environmental protection and high ignition point. FR3 is a natural ester insulating oil that can be used in high voltage transformers above 110 kV. In order t...
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Article
DDI2 promotes tumor metastasis and resists antineoplastic drugs-induced apoptosis in colorectal cancer
The normal colorectal mucosa undergoes precancerous lesions that can develop over time into colorectal cancer (CRC). In the stage of precancerous lesions, DNA replication stress may lead to genome instability....
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Article
Open AccessPalaeobotanical evidence reveals the living conditions of Miocene Lufengpithecus in East Asia
Understanding the relationship between human evolution and environmental changes is the key to lifting the veil on human origin. The hypothesis that environmental changes triggered the divergence of humans fro...
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Article
Pharmacometric model of agalsidase–migalastat interaction in human: a novel mechanistic model of drug-drug interaction between a therapeutic protein and a small molecule
Recently, a new mechanism of drug–drug interaction (DDI) was reported between agalsidase, a therapeutic protein, and migalastat, a small molecule, both of which are treatment options of Fabry disease. Migalast...
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Article
Dielectric properties of Ti4+/Zr4+ modified the SrCeO3-based microwave ceramic systems
A series of new systems of the SrCe1-xTixO3 and SrCe1−xZrxO3 (SCTx and SCZx, x = 0.0–0.1) ceramics have been prepared by the traditional solid-phase methods. The XRD patterns results show that an ABO3-type perovs...
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Article
Phase-tunable single-photon transport in a one-dimensional waveguide with the extra cavity–emitter system
Single-photon scattering properties in a one-dimensional waveguide coupled to the cavity and the two-level atom are investigated theoretically. Two cases are considered: when the one-dimensional waveguide is c...
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Article
Open AccessPast rainfall-driven erosion on the Chinese loess plateau inferred from archaeological evidence from Wucheng City, Shanxi
The history of changes in the Earth’s surface can be investigated by numerical modelling of landform evolution. However, such models rely on evidence which is often removed through erosion or other surface pro...
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Article
Synergistic effect of photo-thermal oxidation for a low concentration of HCHO over Bi3+-TiO2/MnFeOx catalysts at ambient temperature
Formaldehyde (HCHO) has been one of the important air pollutants, and the effective removal of HCHO at ambient temperature has been a big challenge. In this work, the synergistic effect of photo-thermal oxidat...
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Article
Population Pharmacokinetics of Piperacillin/Tazobactam Across the Adult Lifespan
Piperacillin/tazobactam is one of the most frequently used antimicrobials in older adults. Using an opportunistic study design, we evaluated the pharmacokinetics of piperacillin/tazobactam as a probe drug to e...
