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Article

SHARPIN stabilizes β-catenin through a linear ubiquitination-independent manner to support gastric tumorigenesis

Aberrant activation of Wnt/β-catenin signaling by dysregulated post-translational protein modifications, especially ubiquitination is causally linked to cancer development and progression. Although Lys48-linke...

Liang Zhang, Qin Liu, Ke-wei Liu, Zhong-yi Qin, Guang-xi Zhu… in Gastric Cancer (2021)