5 Result(s)
within
Article
Greet Van den Berghe
Biomedicine
Gene Function
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Article
Open AccessAbnormal DNA methylation within HPA-axis genes years after paediatric critical illness
Critically ill children suffer from impaired physical/neurocognitive development 2 years later. Glucocorticoid treatment alters DNA methylation within the hypothalamus–pituitary–adrenal (HPA) axis which may im...
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Article
Open AccessAbnormal DNA methylation within genes of the steroidogenesis pathway two years after paediatric critical illness and association with stunted growth in height further in time
Former critically ill children show an epigenetic age deceleration 2 years after paediatric intensive care unit (PICU) admission as compared with normally develo** healthy children, with stunted growth in he...
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Article
Open AccessLong-term impact of paediatric critical illness on the difference between epigenetic and chronological age in relation to physical growth
Altered DNA-methylation affects biological ageing in adults and developmental processes in children. DNA-methylation is altered by environmental factors, trauma and illnesses. We hypothesised that paediatric c...
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Article
Open AccessDifferential DNA methylation by early versus late parenteral nutrition in the PICU: a biological basis for its impact on emotional and behavioral problems documented 4 years later
The PEPaNIC multicenter randomized controlled trial (RCT) has shown that early administration of supplemental parenteral nutrition (early-PN) as compared with withholding PN for 1 week (late-PN) induced long-t...
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Article
Open AccessTime course of altered DNA methylation evoked by critical illness and by early administration of parenteral nutrition in the paediatric ICU
A genome-wide study identified de novo DNA methylation alterations in leukocytes of children at paediatric intensive care unit (PICU) discharge, offering a biological basis for their impaired long-term developmen...
