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Open AccessPutative novel CSF biomarkers of Alzheimer’s disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort
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Article
Open AccessMisfolded protein oligomers induce an increase of intracellular Ca2+ causing an escalation of reactive oxidative species
Alzheimer's disease is characterized by the accumulation in the brain of the amyloid β (Aβ) peptide in the form of senile plaques. According to the amyloid hypothesis, the aggregation process of Aβ also genera...