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The Selective mGlu5 Receptor Antagonist MTEP, Similar to NMDA Receptor Antagonists, Induces Social Isolation in Rats

It has repeatedly been shown that uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists can mimic certain aspects of positive and negative symptoms of schizophrenia in human volunteers and laboratory ani...

Eliza Koros, Holger Rosenbrock, Gerald Birk, Carmen Weiss… in Neuropsychopharmacology (2007)