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Article
Positional Specificity of Phosphatide Acyl Hydrolase (Phospholipase A)
SNAKE venom phospholipase A was shown by de Haas and van Deenen to release the fatty acid constituent present in the β-ester position of mixed-acid phospholipids obtained by a synthesis de novo1–3. This result co...
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Article
Chemical Structure and Serological Activity of Synthetic and Natural Cardiolipin
CARDIOLIPIN was first isolated by Pangborn1 from ox-heart and this compound proved to be the essential lipid of the antigen in the serodiagnosis of syphilis. Based on hydrolysis investigations, Macfarlane et al.2...
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Article
Does a chemically symmetric bond pattern induce a symmetric conformation of lecithin molecules in membranes?
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Article
Association of lysophosphatidylcholine with fatty acids in aqueous phase to form bilayers
Lysophospholipids have been implicated in a variety of physiological processes1. In vivo lysophospholipids are invariably produced with fatty acids as the product of hydrolysis by phospholipase A2 (ref. 2). There...
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Article
Solution structure of porcine pancreatic phospholipase A2 complexed with micelles and a competitive inhibitor
The three-dimensional structure of porcine pancreatic PLA2 (PLA2), present in a 40 kDa ternary complex with micelles and a competitive inhibitor, has been determined using multidimensional heteronuclear NMR spect...