13 Result(s)
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Article
ANXA3, associated with YAP1 regulation, participates in the proliferation and chemoresistance of cervical cancer cells
Cervical cancer, as one of the most common cancers in women, remains a major health threat worldwide. Annexin A3 (ANXA3), a component of the annexin family, is upregulated in numerous cancers, with no explicit...
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Open AccessExtremely low-coverage whole genome sequencing in South Asians captures population genomics information
The cost of Whole Genome Sequencing (WGS) has decreased tremendously in recent years due to advances in next-generation sequencing technologies. Nevertheless, the cost of carrying out large-scale cohort studie...
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Secretory peptide PdEPF2 enhances drought tolerance by modulating stomatal density and regulates ABA response in transgenic Arabidopsis thaliana
Water deficit limits the growth and productivity of plants worldwide. Improved water use efficiency (WUE) and drought tolerance are important adaptations to address these limitations. In this study, an epiderm...
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Open AccessPacBio-LITS: a large-insert targeted sequencing method for characterization of human disease-associated chromosomal structural variations
Generation of long (>5 Kb) DNA sequencing reads provides an approach for interrogation of complex regions in the human genome. Currently, large-insert whole genome sequencing (WGS) technologies from Pacific Bi...
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Open AccessThe distribution and mutagenesis of short coding INDELs from 1,128 whole exomes
Identifying insertion/deletion polymorphisms (INDELs) with high confidence has been intrinsically challenging in short-read sequencing data. Here we report our approach for improving INDEL calling accuracy by ...
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Open AccessWhole-genome sequencing of Mesorhizobium huakuii 7653R provides molecular insights into host specificity and symbiosis island dynamics
Evidence based on genomic sequences is urgently needed to confirm the phylogenetic relationship between Mesorhizobium strain MAFF303099 and M. huakuii. To define underlying causes for the rather striking differen...
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Open AccessTranslational signatures and mRNA levels are highly correlated in human stably expressed genes
Gene expression is one of the most relevant biological processes of living cells. Due to the relative small population sizes, it is predicted that human gene sequences are not strongly influenced by selection ...
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Open AccessAtlas2 Cloud: a framework for personal genome analysis in the cloud
Until recently, sequencing has primarily been carried out in large genome centers which have invested heavily in develo** the computational infrastructure that enables genomic sequence analysis. The recent a...
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Open AccessCharacterizing linkage disequilibrium and evaluating imputation power of human genomic insertion-deletion polymorphisms
Indels are an important cause of human variation and central to the study of human disease. The 1000 Genomes Project Low-Coverage Pilot identified over 1.3 million indels shorter than 50 bp, of which over 890 ...
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Open AccessThe functional spectrum of low-frequency coding variation
Rare coding variants constitute an important class of human genetic variation, but are underrepresented in current databases that are based on small population samples. Recent studies show that variants alteri...
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Open AccessCharacterization of single-nucleotide variation in Indian-origin rhesus macaques (Macaca mulatta)
Rhesus macaques are the most widely utilized nonhuman primate model in biomedical research. Previous efforts have validated fewer than 900 single nucleotide polymorphisms (SNPs) in this species, which limits o...
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Article
Open AccessGenetic diversity in India and the inference of Eurasian population expansion
Genetic studies of populations from the Indian subcontinent are of great interest because of India's large population size, complex demographic history, and unique social structure. Despite recent large-scale ...
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NrDNA internal transcribed spacer revealed molecular diversity in strains of red seaweed Porphyra yezoensis and genetic insights for commercial breeding
Unraveling the cryptic genetic diversity and selective breeding network in various Porphyra strains is of significance for conservation and utilization of economically important nori crops, for both current and f...
